Abstract: Depression is a kind of mental illness with typical symptoms of depression, slow thinking, and reduced speech and action, which can cause suicide behavior in serious cases. At present, chronic unpredictable mild stress (CUMS) has been widely used in depression research, and its physiological and pathological changes are similar to human depression. This paper reviewed the modeling methods, model evaluation and pathological changes of CUMS, and thought about the above aspects.

Key words: Depression, Chronic unpredictable mild stress, Model, Rats