Research Progress on Biological Characteristics in Naked Mole Rat

doi:10.3969/j.issn.1674-5817.2013.05.016

Abstract

Abstract: As a rodent mammal, the naked mole rat inhabit the arid regions of Africa Kenya, Ethiopia, etc. Owing to its social behavior and ecophysiology, the naked mole rat may be commonly used in biomedical research. Compared with traditional animal models, it has unparalleled advantages in cancer and aging research, mechanistic studies of geriatrics and cardiovascular disease, research and development of pain killers. The naked mole rat, as a new experimental animals, have aroused great concern at home and abroad in recent years.

Key words: Heterocephalus glaber, Biological characteristics, Research

CLC Number:

Q95-33

ZHAO Shan-min, CUI Shu-fang. Research Progress on Biological Characteristics in Naked Mole Rat[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 400-405.

References

[1] Edrey YH, Hanes M, Pinto M, et al.Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research[J]. ILAR J, 2011, 52(1):41-53.
[2] Buffenstein R.Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species[J]. J Comp Physiol B, 2008, 178(4):439-445.
[3] Buffenstein R.The naked mole-rat: a new long-living model for human aging research[J]. J Gerontol A Biol Sci Med Sci, 2005, 60(11):1369-1377.
[4] 孙伟, 汤球, 赵善民, 等. 裸鼹鼠人工饲养繁殖初步研究[J]. 实验动物与比较医学, 2013, 33(4):296-300.
[5] Mooney SJ and Holmes MM. Social condition and oxytocin neuron number in the hypothalamus of naked mole-rats (Heterocephalus glaber)[J]. Neuroscience, 2012, 230C:56-61.
[6] Kutsukake N, Inada M, Sakamoto SH, et al.A distinct role of the queen in coordinated workload and soil distribution in eusocial naked mole-rats[J]. PLoS One, 2012, 7(9):e44584.
[7] Henry EC, Dengler-Crish CM,Catania KC.Growing out of a caste-reproduction and the making of the queen mole-rat[J]. J Exp Biol, 2007, 210(Pt 2):261-268.
[8] Sherman PW, Jarvis JUM,Alexander RD.The biology of the naked mole-rat[M]. Princeton: Princeton University Press, 1991. xvi, 518.
[9] Riccio AP and Goldman BD. Circadian rhythms of body temperature and metabolic rate in naked mole-rats[J]. Physiol Behav, 2000, 71(1-2):15-22.
[10] Park TJ, Lu Y, Juttner R, et al.Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber)[J]. PLoS Biol, 2008, 6(1):e13.
[11] Johansen K, Lykkeboe G, Weber RE, et al.Blood respiratory properties in the naked mole rat Heterocephalus glaber, a mammal of low body temperature[J]. Respir Physiol, 1976, 28(3):303-314.
[12] O’Connor TP, Lee A, Jarvis JU, et al. Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function[J]. Comp Biochem Physiol A Mol Integr Physiol, 2002, 133(3):835-842.
[13] Peterson BL, Larson J, Buffenstein R, et al.Blunted neuronal calcium response to hypoxia in naked mole-rat hippocampus[J]. PLoS One, 2012, 7(2):e31568.
[14] Peterson BL, Park TJ,Larson J.Adult naked mole-rat brain retains the NMDA receptor subunit GluN2D associated with hypoxia tolerance in neonatal mammals[J]. Neurosci Lett, 2012, 506(2):342-345.
[15] Deuve JL, Bennett NC, Britton-Davidian J, et al.Chromosomal phylogeny and evolution of the African mole-rats (Bathyergidae)[J]. Chromosome Res, 2008, 16(1):57-74.
[16] Massarini AI, Barros MA, Ortells M O, et al.Chromosomal polymorphism and small karyotypic differentiation in a group of Ctenomys species from Central Argentina (Rodentia: Octodontidae)[J]. Genetica, 1991, 83(2):131-144.
[17] George W.Conservatism in the karyotypes of two African mole-rats (Rodentia,Bathyergidae)[J]. Int J Mamm Biol, 1979, 44:278-285.
[18] Kim EB, Fang X, Fushan AA, et al.Genome sequencing reveals insights into physiology and longevity of the naked mole rat[J]. Nature, 2011, 479(7372):223-227.
[19] van der Horst G, Maree L, Kotze SH, et al. Sperm structure and motility in the eusocial naked mole-rat, Heterocephalus glaber: a case of degenerative orthogenesis in the absence of sperm competition?[J]. BMC Evol Biol, 2011, 11:351.
[20] Gladyshev VN, Zhang G,Wang J.The naked mole rat genome: understanding aging through genome analysis[J]. Aging (Albany NY), 2011, 3(12):1124.
[21] Liang ST, Mele J, Wu YH, et al.Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)[J]. Aging Cell, 2010, 9(4):626-635.
[22] Seluanov A, Hine C, Azpurua J, et al.Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(46):19352-19357.
[23] Abercrombie M.Contact inhibition and malignancy[J]. Nature, 1979, 281(5729):259-262.
[24] Kim EB, Fang XD, Fushan AA, et al.Genome sequencing reveals insights into physiology and longevity of the naked mole rat[J]. Nature, 2011, 479(7372):223-227.
[25] Liang S, Mele J, Wu Y, et al.Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)[J]. Aging Cell, 2010, 9(4):626-635.
[26] Bennett NC and aulkes CG F.African Mole-Rats: Ecology and Eusociality[M]. Cambridge: Cambridge University Press,2000.
[27] Scialo F, Mallikarjun V, Stefanatos R, et al.Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms[J]. Antioxid Redox Signal, 2012.
[28] Rodriguez KA, Edrey YH, Osmulski P, et al.Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat[J]. PLoS One, 2012, 7(5):e35890.
[29] Yu C, Li Y, Holmes A, et al.RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice[J]. PLoS One, 2011, 6(11):e26729.
[30] Tian X, Azpurua J, Hine C, et al.High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat[J]. Nature, 2013, 499(7458):346-349.
[31] Grimes KM, Lindsey ML, Gelfond J A, et al.Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat[J]. J Gerontol A Biol Sci Med Sci, 2012, 67(4):384-394.
[32] Nathaniel TI, Saras A, Umesiri FE, et al.Tolerance to oxygen nutrient deprivation in the hippocampal slices of the naked mole rats[J]. J Integr Neurosci, 2009, 8(2):123-136.
[33] Larson J and Park TJ. Extreme hypoxia tolerance of naked mole-rat brain[J]. Neuroreport, 2009, 20(18):1634-1637.
[34] Smith ES, Omerbasic D, Lechner SG, et al.The molecular basis of acid insensitivity in the African naked mole-rat[J]. Science, 2011, 334(6062):1557-1560.
[35] Smith ES, Blass GR, Lewin GR, et al.Absence of histamine-induced itch in the African naked mole-rat and “rescue”by Substance P[J]. Mol Pain, 2010, 6:29.
[36] Hetling JR, Baig-Silva MS, Comer CM, et al.Features of visual function in the naked mole-rat Heterocephalus glaber[J]. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2005, 191(4):317-330.
[37] Mills SL and Catania KC. Identification of retinal neurons in a regressive rodent eye (the naked mole-rat)[J]. Vis Neurosci, 2004, 21(2):107-117.
[38] Holmes MM, Goldman BD,Forger NG.Social status and sex independently influence androgen receptor expression in the eusocial naked mole-rat brain[J]. Horm Behav, 2008, 54(2):278-285.
[39] Clarke FM and Faulkes CG. Hormonal and behavioural correlates of male dominance and reproductive status in captive colonies of the naked mole-rat, Heterocephalus glaber[J]. Proc Biol Sci, 1998, 265(1404):1391-1399.
[40] Henry EC, Sarko DK,Catania K C.Central projections of trigeminal afferents innervating the face in naked mole-rats (Heterocephalus glaber)[J]. Anat Rec (Hoboken), 2008, 291(8):988-998.
[41] Smith TD, Bhatnagar K P, Dennis J C, et al.Growth-deficient vomeronasal organs in the naked mole-rat (Heterocephalus glaber)[J]. Brain Res, 2007, 1132(1):78-83.
[42] Kotze SH, Van Der Merwe EL, Bennett NC, et al. The comparative anatomy of the abdominal gastrointestinal tract of six species of African mole-rats (Rodentia, Bathyergidae)[J]. J Morphol, 2010, 271(1):50-60.
[43] Kotze SH, van der Merwe EL, Ndou R, et al. The colonic groove or furrow: a comparative morphological study of six species of African mole-rats (Rodentia, Bathyergidae)[J]. J Morphol, 2009, 270(8):966-975.
[44] Pitcher T and Buffenstein R. Intestinal calcium transport in mole-rats (Cryptomys damarensis and Heterocephalus glaber) is independent of both genomic and non-genomic vitamin D mediation[J]. Exp Physiol, 1995, 80(4):597-608.
[45] McMullen CA, Andrade FH,Crish SD. Underdeveloped extraocular muscles in the naked mole-rat (Heterocephalus glaber)[J]. Anat Rec (Hoboken), 2010, 293(5):918-923.
[46] Quay WB.Pineal atrophy and other neuroendocrine and circumventricular features of the naked mole-rat, Heterocephalus glaber (Ruppell), a fossorial, equatorial rodent[J]. J Neural Transm, 1981, 52(1-2):107-115.
[47] St John Smith E, Purfurst B, Grigoryan T, et al. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae[J]. J Comp Neurol, 2012, 520(12):2785-2803.
[48] Crish SD, Rice FL, Park TJ, et al.Somatosensory organization and behavior in naked mole-rats I: vibrissa-like body hairs comprise a sensory array that mediates orientation to tactile stimuli[J]. Brain Behav Evol, 2003, 62(3):141-151.
[49] Park TJ, Comer C, Carol A, et al.Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain[J]. J Comp Neurol, 2003, 465(1):104-120.
[50] Csiszar A, Labinskyy N, Orosz Z, et al.Vascular aging in the longest-living rodent, the naked mole rat[J]. Am J Physiol Heart Circ Physiol, 2007, 293(2):H919-927.
[51] Peroulakis ME, Goldman B,Forger NG.Perineal muscles and motoneurons are sexually monomorphic in the naked mole-rat (Heterocephalus glaber)[J]. J Neurobiol, 2002, 51(1):33-42.
[52] Kramer B and Buffenstein R. The pancreas of the naked mole-rat (Heterocephalus glaber): an ultrastructural and immunocytochemical study of the endocrine component of thermoneutral and cold acclimated animals[J]. Gen Comp Endocrinol, 2004, 139(3):206-214.
[53] Endo H, Okanoya K, Park TJ, et al.Localization of the cytochrome p450 side-chain cleavage enzyme in the inactive testis of the naked mole-rat[J]. Zoolog Sci, 2002, 19(6):673-678.
[54] Onyango DW, Oduor-Okelo D,Otiang’a-Owiti G E. Ultrastructural study of the testis of non-breeding naked mole-rat (Heterocephalus glaber, Ruppell)[J]. Ann Anat, 1993, 175(5):447-452.
[55] Malinouski M, Kehr S, Finney L, et al.High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3[J]. Antioxid Redox Signal, 2012, 16(3):185-192.
[56] Mitchell TW, Buffenstein R,Hulbert AJ.Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): A comparative study using shotgun lipidomics[J]. Exp Gerontol, 2007, 42(11):1053-1062.
[57] Catania KC and Remple MS. Somatosensory cortex dominated by the representation of teeth in the naked mole-rat brain[J]. Proc Natl Acad Sci U S A, 2002, 99(8):5692-5697.
[58] Henry EC, Marasco PD,Catania KC.Plasticity of the cortical dentition representation after tooth extraction in naked mole-rats[J]. J Comp Neurol, 2005, 485(1):64-74.
[59] Xiao J, Levitt JB,Buffenstein R.A stereotaxic atlas of the brain of the naked mole-rat (Heterocephalus glaber)[J]. Neuroscience, 2006, 141(3):1415-1435.
[60] 林丽芳, 赵懿宁, 赵善民, et al.裸鼹鼠与C57BL6小鼠自噬调节的比较研究[J]. 实验动物与比较医学, 2013, 33(4):301-305.
[61] 袁子彦, 赵懿宁, 张璐, 等. 裸鼹鼠肝脏显微结构与超显微结构观察[J].实验动物与比较医学, 2013, 33(5):373-377.
[62] 袁子彦, 赵懿宁, 张璐, 等. 裸鼹鼠肺脏显微与超显微结构观察[J]. 实验动物与比较医学, 2013, 33(5):378-382.
[63] 袁子彦, 赵懿宁, 张璐, 等. 裸鼹鼠心脏显微与超显微结构观察[J]. 实验动物与比较医学, 2013, 33(5):383-387.
[64] 张璐, 赵懿宁, 袁子彦, 等. 裸鼹鼠与C57BL/6J小鼠肾脏显微及超微结构比较[J].实验动物与比较医学, 2013, 33(5):388-394.
[65] 赵善民, 赵懿宁, 汤球, 等. 裸鼹鼠胸腺、脾脏及淋巴结解剖学、组织学与超微结构观察[J]. 实验动物与比较医学, 2013, 33(5):395-399.