Laboratory Animal and Comparative Medicine ›› 2023, Vol. 43 ›› Issue (1): 86-94.DOI: 10.12300/j.issn.1674-5817.2023.014

• Guidelines for Comparative Medical Research and Reporting • Previous Articles     Next Articles

Introduction to the International Guide for Animal Research Reporting ARRIVE 2.0, and Its Implementation Plan in the Journal

Junyan ZHANG1(), Xiaoyu LIU2(), Yao LI3()(), Guoyuan CHEN4, Xiao LU5, Yu BAI6, Xuancheng LU2, Wanyong PANG7, Baojin WU4()()   

  1. 1.Editorial Office of Laboratory Animal and Comparative Medicine, Shanghai Laboratory Animal Research Center, Shanghai 201203, China
    2.Chinese Center for Disease Control and Prevention, Beijing 102206, China
    3.Department of Laboratory Animal Science, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
    4.Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai 200031, China
    5.Dizal Pharmaceuticals Co. , Ltd. , Shanghai 201203, China
    6.Novo Nordisk Research Centre China, Beijing 102206, China
    7.Translational In Vivo Model Research Platform, Sanofi G&D, Beijing 100022, China
  • Received:2023-01-25 Revised:2023-02-14 Online:2023-02-25 Published:2023-03-09
  • Contact: Yao LI, Baojin WU


Animal experiments play an important role in the process of biomedical research, and is a necessary way to transform basic medicine into clinical medicine. The standardization of animal experimental studies and reports determines the reliability and reproducibility of research results, and is also the key to transforming the results of animal experiments into clinical trials. In view of how to design and implement animal experiments, write animal experiment reports, and publish relevant academic papers in a more standardized way, LACM (Laboratory Animal and Comparative Medicine) has launched a new column of comparative medical research and reporting standards from 2023, focusing on the introduction and interpretation of international general norms related to laboratory animal and comparative medicine, such as ARRIVE 2.0 guidelines (Animal Research: Reporting of In Vivo Experiments). This article focuses on the development and application, basic content and priority of ARRIVE 2.0, as well as the scheme of implementing ARRIVE 2.0 guidelines in international biomedical journals, and explains the current situation and future plans of LACM following ARRIVE 2.0 guidelines. The research and report of animal experimental medicine following the ARRIVE 2.0 guidelines and other international norms is one of the important driving forces to promote the high-quality development of experimental animal science and biomedicine in China, and also a powerful means to implement the 3R principle and improve the welfare of laboratory animals. Through this article, we hope the majority of scientific researchers and editors will attach great importance and actively implement these international standards.

Key words: Animal experiment, Research design, Publication of research papers, ARRIVE 2.0 guidelines, Biomedical journal

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