Research Progress on Premature Ovarian Failure Animal Model induced by Vinylcyclohexene Diepoxide

doi:10.3969/j.issn.1674-5817.2016.05.018

Abstract

Abstract: Premature ovarian failure(POF) is a reproductive system disease as the main characteristics of ovarian function decline in advance.Although the high morbidity, there are few patients found and diagnosed early,which limits the study of the disease. Accordingly establishing the POF animal model which is similar to anthropic reproductive endocrinology and histological changes is of great value to POF pathogenesis reseach and further treatment.In experiments, POF model can be prepared by many methods, but current animal models of POF fail to adequately replicate this particular stage in female life.The article states the research progress of POF model induced by 4-vinylcyclohexene diepoxide (VCD) mainly on the diverse injection concentration, different injection time, disparate day age, distinct species and a large amount of regulatory factors which closely participated in follicular recruitment, growth and apoptosis.

Key words: 4-vinylcyclohexene diepoxide (VCD), Premature ovarian failure (POF), Research progress, Animal model

CLC Number:

Q95-33

GENG Li-hua, TAN Yong. Research Progress on Premature Ovarian Failure Animal Model induced by Vinylcyclohexene Diepoxide[J]. Laboratory Animal and Comparative Medicine, 2016, 36(5): 404-408.

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