Abstract: Congenital cataract is the main cause of blindness in children. The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region successfully constructed mouse models of congenital cataracts. The biological characteristics, behavioral characteristics, gene sequences, and mutant proteins of the model mice were studied, yielding some notable achievements. These novel cataract mouse models may serve as reliable animal models for drug screening and cataract prevention. This paper reviews the research progress on the biological characteristics, behavior, genetics, and mutant proteins of the Rncat congenital cataract mouse model.

Key words: Congenital cataract, Mice, Biological characteristics, Behavioral characteristics