关键词: 动物模型, 肺动脉高压, 左肺逆循环, 双向腔肺吻合, 全腔肺吻合

Abstract: To provide a series studies for influence of the left lung inverse circulation and BCPA on pulmonary physiology and function and probably to use this technique to treat the patients with functional single ventricle with pulmonary hypertension, the reversal model of left pulmonary circulation （RLPC） with bidirectional cavopulmonary anastomosis （BCPA） was established in canines. Six mongrel dogs were chosen to be studied on this model. The procedure of establishing RLPC plus BCPA include anastomose the distal end of left pulmonary artery （LPA） to the left auricle； use a graft tube to connect the proximal LPA to three pulmonary veins and do a end to side anastomosis between supra vena cava and right pulmonary artery.All canines were survived over three days. Echo and angiography showed that there were no remarkable obstruction in left lung inverse circulation and cavopulmonary anastomosis. So the RLPC plus BCPA is technically feasible,it affords a experimental model for in vivo study of pulmonary pathophysiology and haemodynamics in complex congenital heart diseases kids with pulmonary hypertention and it’s a interm palliation and can be transit to total cavapulmonary shunts.

Key words: Animal model, Pulmonary hypertension, Reversal of left pulmonary Circulation, Bidirectional cavopulmonary anastomosis, Total cavopulmonary shunts