实验动物与比较医学 ›› 2022, Vol. 42 ›› Issue (4): 358-363.DOI: 10.12300/j.issn.1674-5817.2021.166

• 实验动物质量控制 • 上一篇    下一篇

实验动物质量控制中泰泽病原体的研究进展

陶俊豪(), 鄢慧琼, 谢珲, 应华忠, 戴方伟()   

  1. 杭州医学院实验动物中心, 浙江省实验动物与安全性研究重点实验室, 杭州 310013
  • 收稿日期:2021-10-27 修回日期:2022-05-12 出版日期:2022-08-25 发布日期:2022-09-01
  • 通讯作者: 戴方伟(1978—),女,副研究员,研究方向:实验动物病原监测研究。E-mail:fangweidai@163.com。ORCID: 0000-0001-6941-9860
  • 作者简介:陶俊豪(1997—),男,硕士,研究方向:实验动物病原检测新技术研究。E-mail:1062024353@qq.com
  • 基金资助:
    浙江省医药卫生科技计划项目“基于LAMP与dipstick集成的实验动物泰泽病原体病快速诊断新技术研究”(2020KY530)

Research Progress of Tyzzer’s Organism in Quality Control of Laboratory Animals

Junhao TAO(), Huiqiong YAN, Hui XIE, Huazhong YING, Fangwei DAI()   

  1. Zhejiang Provincial Laboratory of Experimental Animal and Safety Evaluation Research, Laboratory Animal Center, Hangzhou Medical College, Hangzhou 310013, China
  • Received:2021-10-27 Revised:2022-05-12 Online:2022-08-25 Published:2022-09-01
  • Contact: DAI Fangwei (ORCID: 0000-0001-6941-9860), E-mail: fangweidai@163.com

摘要:

泰泽病原体(Tyzzer’s organism)是一种能引起实验动物肝肠坏死和腹泻的毛发状芽孢杆菌(Clostridium piliforme,旧称Bacillus piliformis)。该病原体引起的泰泽病是一种急性疾病,其发病迅速、致死率高、临床症状不明显,往往难以进行早期诊断和治疗,一旦爆发,将会造成严重的经济损失和实验室安全问题。本文从泰泽病原体的生物学特性、流行病学与疾病特征、检测方法、研究进展及防治多个方面进行综述。

关键词: 泰泽病原体, 泰泽氏病, 研究进展, 防治

Abstract:

Tyzzer's organism is a kind of Clostridium piliforme, formerly Bacillus piliformis, which can cause hepatointestinal necrosis and diarrhea in animals. Tyzzer's disease caused by this pathogen is an acute disease with rapid onset, high mortality and no obvious clinical symptoms, so it is difficult to make early diagnosis and treatment. Once the outbreak, it will cause irreparable economic losses and laboratory safety problems. This article reviewed the biological characteristics, epidemiological and disease characteristics, detection methods, research progress of Tyzzer's organism, as well as the prevention and treatment of Tyzzer's organism.

Key words: Tyzzer organism, Tyzzer disease, Research progress, Prevention and treatment

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