关键词: 泛酸钠, 心电图指标, 血压, 心率, Beagle犬

Abstract: Objective To observe the general influence of sodium pantothenate on the cardiovascular indicators of Beagle dogs. Method Sixteen healthy Beagle dog with half female and male. They were randomly divided into four groups: high, medium and lower dose of sodium pantothenate with 0.26 mg/kg, 0.52 mg/kg, 1.04 mg/kg and normal saline control group (NS). The dogs were anesthetized with intravenous injection of 3% pentobarbital sodium. The unilateralcarotid artery was dissociated so as to insert the artery cannulae for measuring systolic and diastolic blood pressure. Then unilateralfemoral vein is isolated for a single intravenous injection of 1 mL/kg sodium pantothenate, and electrodes were placed into their limbs to record the indexs of blood pressure, heart rate and electrocardiograph before administration and at different time points after drug administration while each observation index of the Beagle dogs was constant. Result In this experiment, sodium pantothenate did not evidently change the value of blood pressure, heart rate and electrocardiographic in Beagle dogs after intravenous injection (P>0.05). Conclusion The sodium pantothenate has no evident effects on the cardiovascular indicators of Beagle dogs.

Key words: Sodium pantothenate, electrocardiograph (ECG) index, Blood pressure, Heart rate