替米沙坦对慢性间断性缺氧小鼠血压的影响

doi:10.3969/j.issn.1674-5817.2012.05.007

实验动物与比较医学 ›› 2012, Vol. 32 ›› Issue (5): 407-410.DOI: 10.3969/j.issn.1674-5817.2012.05.007

• 华东地区第12 届实验动物科学学术交流会优秀论文选刊 • 上一篇下一篇

替米沙坦对慢性间断性缺氧小鼠血压的影响

何宏星¹, 曾奕明², 陈晓阳², 王婉瑜³

1.福建医科大学实验动物中心, 福州350004;
2.福建医科大学附属第二医院, 泉州362000;
3.厦门市第一医院, 厦门361004

收稿日期:2012-01-31 出版日期:2012-10-25 发布日期:2012-10-25
作者简介:何宏星(1976-),男,实验师,研究方向:实验动物和动物实验管理
基金资助:
福建省科技平台建设(2008L001);福建省教育厅科技项目(7A09120)

Effect of Telmisartan on Blood Pressure of Mice under Intermittent Hypoxia Condition

HE Hong-xing¹, ZHENG Yi-min², CHEN Xiao-yang², WANG Wan-yu³

1. Department of Laboratory Animal Science, Fujian Medical University, Fuzhou 350004, China;
2. The Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000 China;
3. First Hospital of Xiamen, Xiamen 361004, China

Received:2012-01-31 Online:2012-10-25 Published:2012-10-25

摘要/Abstract

摘要： 目的通过探索睡眠呼吸暂停综合征(sleep apnea syndrome, SAS)引起的慢性间断性缺氧(chronic intermittent hypoxia, CIH)对肾素-血管紧张素系统(renin angiotensin system, RAS)影响及血管紧张素受体阻滞剂(Angiotensin Receptors Blocker, ARB)的保护作用。方法将32只清洁级雄性C57BL/6J小鼠随机分为CIH组、ARB替米沙坦干预组、空气模拟对照组和空白对照组,进行12周的模型试验。检测实验小鼠血压及鼠尾血流。结果 (1)小鼠收缩压：CIH组小鼠收缩压高于ARB干预组、空气模拟对照组、空白对照组。ARB干预组收缩压则低于其余三组。(2)小鼠舒张压: ARB干预组小鼠舒张压低于其余三组。(3)鼠尾组织血流: CIH组小鼠组织血流量明显高于其他三组。结论慢性间断性缺氧可引起收缩压升高,ARB有良好的降压作用。慢性间断性缺氧可引起小鼠鼠尾组织血流量增多,ARB可逆转这种改变。

关键词: 慢性间断性缺氧, 睡眠呼吸暂停综合征, ARB, 血压

Abstract: Objective To observe the effect of chronic intermittent hypoxia in sleep apnea syndrome patients on renin angiotensin system and the protection of angiotensin receptors blocker on cardiovascular system, so as to explore the mechanism which sleep apnea syndrome act on cardiovascular system. Methods Thirty-two healthy male C57BL/6J mice were randomly divided into 4 groups: the CIH group, the telmisartan treatment group, the air control group, and the blank control group, with 8 mice in each group. The period of chronic intermittent hypoxia was lasted for 12 weeks. The blood pressure and blood flow of mouse tail were measured. Results (1) The level of systolic blood pressure in the CIH group was significantly higher than other groups and came down to the lowest after ARB treatment. (2) The level of diastolic blood pressure in ARB treatment group was significantly lower than other groups. (3) The tail blood flow of CIH group was significantly higher than those of the blank control group, the air control group, and the ARB treatment group. Conclusion The chronic intermittent hypoxia might induce high systolic blood pressure, and that ARB could decrease the hypertension caused by CIH. At the same time, CIH could increase the tail blood flow of mouse, and ARB could inverse this influence of CIH.

Key words: Chronic intermittent hypoxia, Sleep apnea syndromes, ARB, Blood pressure

中图分类号:

Q95-33

何宏星, 曾奕明, 陈晓阳, 王婉瑜. 替米沙坦对慢性间断性缺氧小鼠血压的影响[J]. 实验动物与比较医学, 2012, 32(5): 407-410.

HE Hong-xing, ZHENG Yi-min, CHEN Xiao-yang, WANG Wan-yu. Effect of Telmisartan on Blood Pressure of Mice under Intermittent Hypoxia Condition[J]. Laboratory Animal and Comparative Medicine, 2012, 32(5): 407-410.

参考文献

[1] Rey S, Valdés G, Iturriaga R.Pathophysiology of obstructive sleep apnea-associated hypertension[J]. Rev Med Chil, 2007,135(10):1333-1342.
[2] 常小荣, 彭娜, 易受乡, 等. 艾灸足三里和梁门穴诱导热休克蛋白70抗大鼠胃黏膜氧化损伤作用[J]. 世界华人消化杂志, 2006, 14(35):3405-3408.
[3] Foster GE, Poulin MJ, Hanly PJ.Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea[J]. Exp Physiol, 92(1):51-65.
[4] Tasali E, Ip MS.Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation[J]. Proc Am Thorac Soc, 2008, 5(2):207-217.
[5] Rey S, Valdés G, Iturriaga R.Pathophysiology of obstructive sleep apnea-associated hypertension[J]. Rev Med Chil Epub,2007, 135(10):1333-1342.
[6] Yuan ZM, Chen BY, Wang PX, et al.Changes of angiotensin II and its receptor during the development of chronic intermittent hypoxia-induced hypertension in rats[J]. Zhonghua Jie He He Hu Xi Za Zhi, 2004,27(9):577-580.
[7] Lai CJ, Yang CC, Hsu YY, et al.Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats[J]. J Appl Physiol, 2006, 100(6):1974-1982.
[8] Lau AK, Chaufour X, McLachlan C, et al. Intimal thickening after arterial balloon injury is increasedby intermittent repetitive hypoxia, but intermittent repetitive hyperoxia is not protective[J]. Atherosclerosis, 2006, 185(2):254-263.
[9] Baylor P, Mouton A, Shamoon HH, et al.Increased norepinephrine variability in patients with sleep apnea syndrome[J]. Am J Med, 1995, 99(6):611-615.
[10] Narkiewicz K, Kato M, Phillips BG, et al.Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea[J]. Circulation, 1999, 100:2332.
[11] Kraiczi H, Caidahl K, Samuelsson A, et al.Impairment of vascular endothelial function and left ventricular filling association with the severity of apnea-induced hypoxemia during sleep[J]. Chest, 2001, 119:1085-1091.
[12] Xie AL, Skatrud JB, Crabtree DC, et al.Neurocirculatory consequences of intermittent asphyxia in humans[J]. J App Physiol, 2000, 89:1333-1339.

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替米沙坦对慢性间断性缺氧小鼠血压的影响

Effect of Telmisartan on Blood Pressure of Mice under Intermittent Hypoxia Condition

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