不同年龄段自发性高血压大鼠脉搏波传导速度和动脉管壁结构的观察

doi:10.3969/j.issn.1674-5817.2020.02.009

实验动物与比较医学 ›› 2020, Vol. 40 ›› Issue (2): 141-143.DOI: 10.3969/j.issn.1674-5817.2020.02.009

所属专题：实验动物资源开发与利用

不同年龄段自发性高血压大鼠脉搏波传导速度和动脉管壁结构的观察

郭菁¹, 顾文勇¹, 吴永杰^1,2

1.上海交通大学医学院附属瑞金医院, 上海 200025;
2.上海市高血压研究所, 上海市高血压重点实验室, 上海 200025

收稿日期:2019-11-23 出版日期:2020-04-25 发布日期:2020-12-18
作者简介:郭菁(1968-), 主管药师, 从事药物机制研究。 E-mail: gj40292@rjh.com.cn

Observation of Pulse Wave Velocity and Arterial Wall Structure in Spontaneously Hypertensive Rats at Different Ages

GUO Jing¹, GU Wenyong¹, WU Yongjie^1,2

1. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;
2. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Shanghai 200025, China

Received:2019-11-23 Online:2020-04-25 Published:2020-12-18

摘要/Abstract

摘要： 目的通过对不同年龄段自发性高血压大鼠(SHR)的脉搏波传导速度(PWV)的测定,以及同期SHR主动脉中膜横截面积 (MCSA)结构分析,揭示SHR不同生长阶段血管生理变化。方法使用彩色超声多普勒和测定血管病理分析对4月龄、6月龄、8月龄、10月龄、12月龄的SHR进行PWV测定及MCSA分析。结果随年龄的增长, SHR的PWV开始升高。12月龄SHR的PWV显著高于8月龄、6月龄及4月龄组大鼠(P<0.05)。10月龄SHR的PWV显著高于6月龄组和4月龄组大鼠(P<0.05)。MCSA分析显示,随着年龄的增加,SHR主动脉MCSA也呈现逐步上升的趋势。结论随着年龄的增长,SHR动脉顺应性变差,血管弹性功能降低,动脉硬化程度增强。

关键词: 自发性高血压大鼠, 脉搏波传导速度, 中膜横截面积

Abstract: Objective To reveal the physiological changes of blood vessels in different growth stages of spontaneous hypertensive rats (SHR) by measuring the pulse wave velocity (PWV) and analyzing the structure of aortic media cross-sectional area (MCSA) in the same period of SHR. Methods Color Doppler ultrasonography and vascular pathological analysis were used to determine PWV and MCSA of SHR at 4, 6, 8, 10 and 12 month of age. Results The PWV of 12-month-old SHR was significantly higher than that of 8-month-old, 6-month-old and 4-month-old SHR respectively(P<0.05). The PWV of 10-month-old SHR was significantly higher than that of 6-month-old and 4-month-old SHR respectively (P<0.05). Meanwhile, the MCSA analysis of SHR showed that the aortic MCSA of SHR increased gradually with age. Conclusion With the increase of age, the arterial compliance of SHR is worse, the vascular elasticity is decreased, and the degree of atherosclerosis is enhanced.

Key words: Spontaneous hypertensive rat, Pulse wave velocity, Media cross-sectional area

中图分类号:

Q95-33

郭菁, 顾文勇, 吴永杰. 不同年龄段自发性高血压大鼠脉搏波传导速度和动脉管壁结构的观察[J]. 实验动物与比较医学, 2020, 40(2): 141-143.

GUO Jing, GU Wenyong, WU Yongjie. Observation of Pulse Wave Velocity and Arterial Wall Structure in Spontaneously Hypertensive Rats at Different Ages[J]. Laboratory Animal and Comparative Medicine, 2020, 40(2): 141-143.

[1]	曹爽, 丁建伟, 李炳, 袁丽粉, 杜勤. 慢性束缚应激诱导自发性高血压大鼠出现抑郁焦虑样行为[J]. 实验动物与比较医学, 2014, 34(2): 93-97.
[2]	杨鹏翔, 姬宏飞, 杨艳梅, 马占好, 杨悦. SHR大鼠血液生理生化指标的测定[J]. 实验动物与比较医学, 2012, 32(5): 449-452.
[3]	夏春梅，丁爽爽，奚剑飞，张周. L-NAME加剧自发性高血压大鼠肾脏硬化[J]. , 2003, 23(4): 207-211.
[4]	杨伟敏，朱正伟，屠泽华，姚一康，尹松林. 自发性高血压大鼠专用饲料研制初报[J]. , 2003, 23(3): 176-177.
[5]	吴永杰. 环境温度和湿度对自发性高血压大鼠增重和离乳率的影响[J]. , 1999, 19(2): 112-112.
[6]	许昌声, 王华军, 林志鸿. 自发性高血压大鼠血管结构与功能的观察[J]. , 1999, 19(1): 38-40.
[7]	袁进, 顾为望, 林继红, 邱添武. 加喂奶粉对自发性高血压大鼠繁殖性能的影响[J]. , 1998, 18(2): 98-99.
[8]	顾德官, 张玉珍. 易卒中自发性高血压大鼠观察[J]. , 1996, 16(3,4): 167-169.
[9]	顾德官. 易卒中自发性高血压大鼠尸检所见[J]. , 1996, 16(1): 36-38.

不同年龄段自发性高血压大鼠脉搏波传导速度和动脉管壁结构的观察

Observation of Pulse Wave Velocity and Arterial Wall Structure in Spontaneously Hypertensive Rats at Different Ages

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