关键词: 慢性肾功能衰竭, 肾虚型, 比格犬, 动物模型, 肾皮电灼法, 肾动脉结扎

Abstract: Objective To study the surgical method for establishing chronic renal failure model at azotaemic stage in beagle dogs. Methods The integrative operation was preformed by electric cautery of renal cortex and renal artery ligation in left kidney. Right kidney was removed one week later. Blood urea nitrogen and creatinine were detected 3 days after surgery and every week after surgery. Results The urea nitrogen was 7.21±0.72 mmol/L and the creatinine was 82.40±9.42 µmol/L before surgery, 30 days after surgery was 11.22±5.69 mmol/L and 125.55±68.50 µmol/L respectively. Both of their P- value were less than 0.05. Conclusions Ideal chronic renal failure model at azotaemic stage in beagle dogs can be obtained by the combination of electric cautery of left renal cortex and left renal artery ligation.

Key words: Chronic renal failure, Deficiency of the kidney, Beagle dog, Animal model