›› 1995, Vol. 15 ›› Issue (3): 140-142.

• 论文 • 上一篇    下一篇

杏仁内侧核微量注射AVP和AVPMcAb对兔ET性发热效应的影响

  

  1. 解放军兰州医学高等专科学校
  • 收稿日期:1994-12-28 出版日期:1995-01-25 发布日期:2013-03-19

Effect of Microinjection of AVP and AVPMcAb into Medial Amygdaloid Nucleus on Endotoxin-induced Fever in Rabbits

  1. Department of Physiology, Lanzhou Military Medical College of PL A, Lanzhou 730020
  • Received:1994-12-28 Online:1995-01-25 Published:2013-03-19

摘要: 在杏仁内侧核微量注射精氨酸加压素(AVP)和精氨酸加压素单克隆抗体(AVPMc-Ab),观察其对兔内毒素(ET)性发热效应的影响。结果表明,杏仁内侧核微量注射AVP能明显抑制兔ET性发热效应,注射AVPMcAb则能明显提高兔ET性发热效应;而将AVP和AVPMCAb注射到杏仁外侧核则对兔ET性发热效应无明显影响。提示:杏仁内侧核也是AVP抗热作用的一个重要作用部位。

关键词: 精氨酸加压素, 单克隆抗体, 杏仁内侧核, 发热, 抗热作用,

Abstract: "The experiments were undertaken to investigate the effects of microinjection of arginine vasopressin (AVP) and arginine vasopressin monoclonal antibody (AVPMcAb) into the medial amygdaloid nucleus (meA) on endotoxin-induced fever in rabbits. The results were as follows:①Injection of AVP into meA markedly suppressed en-dotoxin-induced fever. Injection of AVPMcAb into meA markedly augmented and prolonged fever responses. (2) Injection of AVP or AVPMcAb alone into lateral amygdaloid nucleus did not influence febrile responses. These results provided evidences that AVP might act within the meA to evoke antipyresis. "

Key words: "Arginine vasopression, Medial amygdaloid nucleus, Fever, Anti-pyresis, Rabbit "