碘标对碘-γ，γ二甲基-苯乙胺在大鼠体内的分布及动力学研究

›› 1995, Vol. 15 ›› Issue (3): 143-145.

碘标对碘-γ，γ二甲基-苯乙胺在大鼠体内的分布及动力学研究

江苏省原子医学研究所

收稿日期:1994-09-22 出版日期:1995-01-25 发布日期:2013-03-19
基金资助:
国家自然科学基金会资助项目

Tissue Distribution and Pharmacokinetics of ¹²⁵I labeled p-Iodophentermine as a Brain Perfusion Imaging Agent in Rat

Jiangsu Institue of Nuclear Medicine,Wuxi 214063

Received:1994-09-22 Online:1995-01-25 Published:2013-03-19

摘要/Abstract

摘要： 报道了脑灌注显像剂碘标记对碘-γ，γ-二甲基一苯乙胺（p-lodphentermine）在大鼠体内的分布及动力学研究，并与其它几种已在临床应用的碘标记胺类脑显像剂：131ⅠIMP（N-isopropyl-4iodoamphetamine），¹³¹Ⅰ-HIPDM[N，N，N’-trimetnyl-N’-（2-hyd-roxy-3-methyl-5-iodobenzyl）-1，3-propanediamine]等作了对比结果表明该药物由于分子结构上引入了甲基，提高了亲脂性，从而易于通过血脑屏障，有可能成为一种更好的脑灌注显像剂。

关键词: 对碘－&gamma, &gamma, －二甲基－苯乙胺, 脑灌注显像剂, 二房室模型, 分布, 药物动力学

Abstract: The tissue distribution and pharmacokinetics of 125I labeled p-iodophentermine (¹²⁵I-IP) as a brain perfusion imaging agent in SD rats was studied and compared with those of the other two 125I labeled amine brain imaging agents ¹²⁵I-IMP (N-isopropyl-4-iodoamphetamine) and ¹²⁵I-HIPDM [N, N,N'-trimethy 1-N'-(2-hydraxy-3-methyl-5-iodobenzyl)-l，3-propanediamine]. The results showed that the lipo-philicity of ¹²⁵I-IP is increased by substituting, with methyls, which makes the agent easier to pass through the blood-brain barrier.

Key words: p-iodophentermine, Braine perfusion imaging agent, Two compartments model, Distribution, Pharmacokinetics, Rat

张荣军, 李卫一, 曹国宪, 穆正明. 碘标对碘-γ，γ二甲基-苯乙胺在大鼠体内的分布及动力学研究[J]. , 1995, 15(3): 143-145.

ZHANG Rong-Jun, LI Wei-Yi, CAO Guo-Xian, MU Zheng-Ming. Tissue Distribution and Pharmacokinetics of ¹²⁵I labeled p-Iodophentermine as a Brain Perfusion Imaging Agent in Rat[J]. , 1995, 15(3): 143-145.

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