实验动物与比较医学 ›› 2013, Vol. 33 ›› Issue (3): 243-246.DOI: 10.3969/j.issn.1674-5817.2013.03.017

• 综述 • 上一篇    下一篇

东方田鼠抗日本血吸虫病相关免疫学研究进展

邵国艳1,3, 谢建云2, 高诚2   

  1. 1.复旦大学,上海 200032;
    2.上海实验动物研究中心,上海 201203;
    3.上海市计划生育科学研究所, 上海200032
  • 收稿日期:2012-08-19 出版日期:2013-06-25 发布日期:2013-06-25
  • 作者简介:邵国艳(1988-), 女, 硕士, 研究方向: 动物学,E-mail: shaogy0806@163.com
  • 基金资助:
    上海市科学基金资助项目(No.11140902801)

Progress on Immune Mechanism of Microtus fortis in Protecting against Schistosoma japonicum Infection

SHAO Guo-yan1,3, XIE Jian-yun2, GAO Cheng2   

  1. 1. Fudan University, Shanghai 201203, China;
    2. Shanghai Laboratory Animal Research Center, Shanghai 201203, China;
    3. Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China
  • Received:2012-08-19 Online:2013-06-25 Published:2013-06-25

摘要: 东方田鼠是一种可以感染血吸虫但是感染后不致病的哺乳动物,体内可能存在对日本血吸虫先天的、可遗传的抗性机制。近年来随着东方田鼠实验动物化,人们对东方田鼠的这种抗性机制进行了深入研究。本文对近几年东方田鼠抗日本血吸虫病相关免疫学研究进展做一综述,从非特异性免疫和特异性免疫角度对东方田鼠这一特殊抗性进行总结及展望。

关键词: 东方田鼠, 日本血吸虫病, 免疫学机制

Abstract: Microtus fortis (Mf) can be infected with Schistosoma japonicum but without any pathogenic clinical symptom. Mf has a congenital, hereditary resistance mechanism against the infection of Schistosoma japonicum. In recent years, since Mf is acclimated into an experimental animal, the resistance mechanism was deeply investigated by many researchers, this review summarize relative study progress from the aspect of specific and non-specific immunity of Mf.

Key words: Microtus fortis, Schistosoma japonicum, Immune resistance mechanism

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