Abstract: Pre-eclampsia (PE) is a common obstetrical and gynecological disease with the hypertension, proteinuria and edema as the main clinical symptom, and accompanying with multiple organ damages. The disease is a serious threat to maternal and child safety and the leading cause of maternal and perinatal morbidity. However, the etiology and pathogenesis of PE is not clarified yet. Using animal models of PE to research human diseases is an important mean to clarify the pathogenesis of the disease or drug efficacy. There are four methods of PE animal modeling: environmental stimulation, chemical drug interference, surgical intervention and gene intervention. Rats and mice are mainly selected to prepare animal models of the PE. In addition, rabbits, dogs, rhesus monkeys, baboons and sheep are also commonly used for preparing the animal models by surgical intervention. In this paper, the preparation methods of PE animal models were reviewed, and the evaluation standards and characteristics of these animal models were introduced.

Key words: Pre-eclampsia(PE), Animal model, Preparation, Review