Research Progress of Animal Models of Stress Cardiomyopathy

doi:10.12300/j.issn.1674-5817.2022.102

Abstract

Abstract:

Stress cardiomyopathy (SC) is an acute cardiomyopathy caused by intense mental stimulation or physical stress. Currently, few interventions are effective in reducing mortality, improving prognosis, or preventing recurrence in acute or chronic stages of SC. Therefore, it is particularly important to establish a reliable and effective SC animal model to study the pathogenesis and prevention of SC. In this paper, the preparation methods and evaluation indexes of SC models at home and abroad were reviewed, including the operation details of catecholamine hormone injection method, binding method, binding combined with electroshock method, binding combined with dehydration method, vagus nerve electrical stimulation and other modeling methods, as well as evaluation indexes such as open field test, cardiac ultrasound, electrocardiogram and ELISA, striving to provide useful reference for model selection and establishment of SC research.

Key words: Stress cardiomyopathy, Animal model, Modeling method, Evaluation index

CLC Number:

R-332

Haosheng WU, Hang SU, Chao ZHU, Wenhui WANG, Shengbing WU, Shuai CUI, Meiqi ZHOU. Research Progress of Animal Models of Stress Cardiomyopathy[J]. Laboratory Animal and Comparative Medicine, 2023, 43(2): 173-179.

Figures/Tables 3

References 43

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动物 Animal	品种或品系 Stock or strain	性别 Sex	年龄或体质量 Age/weight	药物 Drug	剂量 Dose	给药方案 Dosage regimen	参考文献 Reference
大鼠 Rat	SD	雄	250～300 g	ISO	50 mg/kg	单次腹腔注射	[9]
	SD	雌	2～4月龄，241±55 g	ISO	100 mg/kg	单次腹腔注射	[13]
	SD	雄	220～250 g，8周龄	ISO	100 mg/kg	不同部位多点皮下注射，持续3周	[14]
	SD	雌	300～350 g	NE	2～4 mg/kg	单次腹腔注射	[12]
	SD	雌	300～350 g	NE	4 mg/kg	单次腹腔注射	[15]
小鼠Mice	C57BL/6J	雄/雌	8～16周龄	ISO	200 mg/kg	单次腹腔注射	[16]
	C57BL/6J	/	16周	ISO	400 mg/kg	单次腹腔注射	[17]
	C57BL/6J	雄性	7周龄，20～25 g	ISO	50 mg/kg	腹腔注射3周	[18]
	129/Sv	/	8周	ISO	25 mg/kg	连续皮下注射5 d	[19]
	C57BL/ 6J	雄/雌	8周	ISO	30 mg/kg	皮下埋置微渗透泵，连续21 d释放ISO	[20]

动物 Animal	品种或品系 Stock or strain	性别 Sex	年龄或体质量 Age/weight	药物 Drug	剂量 Dose	给药方案 Dosage regimen	参考文献 Reference
大鼠 Rat	SD	雄	250～300 g	ISO	50 mg/kg	单次腹腔注射	[9]
	SD	雌	2～4月龄，241±55 g	ISO	100 mg/kg	单次腹腔注射	[13]
	SD	雄	220～250 g，8周龄	ISO	100 mg/kg	不同部位多点皮下注射，持续3周	[14]
	SD	雌	300～350 g	NE	2～4 mg/kg	单次腹腔注射	[12]
	SD	雌	300～350 g	NE	4 mg/kg	单次腹腔注射	[15]
小鼠Mice	C57BL/6J	雄/雌	8～16周龄	ISO	200 mg/kg	单次腹腔注射	[16]
	C57BL/6J	/	16周	ISO	400 mg/kg	单次腹腔注射	[17]
	C57BL/6J	雄性	7周龄，20～25 g	ISO	50 mg/kg	腹腔注射3周	[18]
	129/Sv	/	8周	ISO	25 mg/kg	连续皮下注射5 d	[19]
	C57BL/ 6J	雄/雌	8周	ISO	30 mg/kg	皮下埋置微渗透泵，连续21 d释放ISO	[20]

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