Abstract: Objective To establish the model of gastric bypass surgery (RYGB) in SD rats, and to study the effect of gastric bypass surgery on weight loss. Methods Thirty five male SD rats were randomly divided into three groupsłşgastric bypass surgery was performed in 15 male rats as the study group (O group), sham operation was performed in 10 male rats which were given diet control after operation as the study control group (C group), and laparotomy was performed in 10 male rats which were given normal diet control after operation as the blank control group (B group). Body weight and food intake were recorded before and after surgery. Results The number of death rats was 7 in the study group, and the survival rate is 53.3%; the maximum weight loss was happened in the first week after surgery, thereafter weight rebounded slower than group B and C (P<0.05). Conclusions It is feasible to established gastric bypass surgery model in rats. RYGB can control weight of rat effectively.

Key words: Animal model, Gastric bypass surgery, Weight loss