Research Progress on Animal Model of Partial Bladder Outlet Obstruction

doi:10.3969/j.issn.1674-5817.2018.06.012

Abstract

Abstract: Constructing an ideal animal model of bladder outlet partial obstruction (pBOO) is the key to study the pathogenesis of bladder obstructive diseases and conduct drug therapy research. In this article, we summarized the animal model induction methods, including the characteristics and limitations of animal models induced by suprapubic bladder neck ligation, extraurethral splenic suture, and subcutaneous hyaluronate injection outside the urethra, and the characteristics and disadvantages of induced pBOO model.

Key words: Partial bladder outlet obstruction (pBOO), Animal model, Lower urinary tract symptoms, Urodynamics

CLC Number:

Q95-33

CHEN Lin, YANG Ya-fei, YANG Jin, HE Pin-lin, WANG Kai, WANG Yun-han, WANG Zi-li. Research Progress on Animal Model of Partial Bladder Outlet Obstruction[J]. Laboratory Animal and Comparative Medicine, 2018, 38(6): 463-467.

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