Replication and Evaluation of Irritable Bowel Syndrome Animal Models

doi:10.3969/j.issn.1674-5817.2012.02.019

Abstract

Abstract: The article summarized the replication methods and evaluation indicators of irritable bowel syndrome animal models. Combined with peripheral sensitization, relatively mild stress stimulus method was a relatively better choice which was to enhance the success rate of molding and consider animal welfare. Defecation frequency and character was the most intuitive and economic indicator in evaluation, but its specificity was poor. Intestinal sensitivity was the most specific indicator which depended on the detection of stress and correlated with clinical research.

Key words: Irritable bowel syndrome, Animal models, Replication, Evaluation indicators

CLC Number:

Q959.9

LIU Yan-xia, LIU Lei, LIU Jun-kang. Replication and Evaluation of Irritable Bowel Syndrome Animal Models[J]. Laboratory Animal and Comparative Medicine, 2012, 32(2): 165-169.

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