Laboratory Animal and Comparative Medicine ›› 2023, Vol. 43 ›› Issue (1): 61-66.DOI: 10.12300/j.issn.1674-5817.2022.130

• Development and Utilization of Laboratory Animal Resources • Previous Articles     Next Articles

Histological Characteristics of the Kidney in Mongolian Gerbils of Different Ages

Lingqun LU(), Honggang GUO, Qiaojuan SHI, Fangwei DAI, Xiaofeng CHU()   

  1. Experimental Animal Center of Hangzhou Medical College, Zhejiang Provincial Key Laboratory of Laboratory Animal and Safety Research, Hangzhou 310000, China
  • Received:2022-08-19 Revised:2022-09-23 Online:2023-02-25 Published:2023-03-09
  • Contact: Xiaofeng CHU

Abstract:

Objective To explore the histological characteristics of the kidney in Mongolian gerbils of different ages. Methods Ten Mongolian gerbils of 2, 6, and 12 months old (half male and half female) were selected. After euthanasia, the kidneys were taken and paraffin sections were made. After HE, MASSON and PAS staining, the structural differences of different parts of the kidney tissue in gerbils of different ages were observed by digital scanning, and the relevant data of the kidney tissue were measured by image analysis software. Results The number of proximal convoluted tubules was more than that of distal convoluted tubules in the renal cortex and outer medulla of gerbils. With age, the glomerular density decreased, the glomerular diameter increased, the basement membrane of renal tubules thickened, and the fibrous components between renal tubules increased. Conclusion The histological structure of Mongolian gerbil's kidney varies with age, which may be related to glomerulosclerosis and parenchymal cell reduction. The specific mechanism needs further study.

Key words: Mongolian gerbil, Kidney, Histological change

CLC Number: