Histological Characteristics of the Kidney in Mongolian Gerbils of Different Ages

doi:10.12300/j.issn.1674-5817.2022.130

Abstract

Abstract:

Objective To explore the histological characteristics of the kidney in Mongolian gerbils of different ages. Methods Ten Mongolian gerbils of 2, 6, and 12 months old (half male and half female) were selected. After euthanasia, the kidneys were taken and paraffin sections were made. After HE, MASSON and PAS staining, the structural differences of different parts of the kidney tissue in gerbils of different ages were observed by digital scanning, and the relevant data of the kidney tissue were measured by image analysis software. Results The number of proximal convoluted tubules was more than that of distal convoluted tubules in the renal cortex and outer medulla of gerbils. With age, the glomerular density decreased, the glomerular diameter increased, the basement membrane of renal tubules thickened, and the fibrous components between renal tubules increased. Conclusion The histological structure of Mongolian gerbil's kidney varies with age, which may be related to glomerulosclerosis and parenchymal cell reduction. The specific mechanism needs further study.

Key words: Mongolian gerbil, Kidney, Histological change

CLC Number:

R-332

Lingqun LU, Honggang GUO, Qiaojuan SHI, Fangwei DAI, Xiaofeng CHU. Histological Characteristics of the Kidney in Mongolian Gerbils of Different Ages[J]. Laboratory Animal and Comparative Medicine, 2023, 43(1): 61-66.

Figures/Tables 3

References 22

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测量指标 Measurement index	2月龄 2 months old	6月龄 6 months old	12月龄 12 months old	合计 Total
髓质厚度/皮质厚度 Thickness of medulla/cortex	3.99±1.34	3.82±0.68	3.36±0.97	3.61±1.20
外髓质厚度/皮质厚度 Thickness of outer medulla/cortex	0.91±0.24	0.95±0.16	0.84±0.33	0.90±0.25
内髓质面积/皮质面积 Area of internal medulla/cortex	0.30±0.10	0.26±0.09	0.35±0.37	0.31±0.24
内髓质面积/肾脏面积 Area of internal medulla/kidney	0.17±0.04	0.16±0.04	0.17±0.11	0.17±0.07
髓质面积/皮质面积 Area of medulla/cortex	0.68±0.28	0.64±0.25	0.78±0.43	0.70±0.33
外髓质面积/皮质面积 Area of outer medulla/cortex	0.38±0.19	0.38±0.17	0.42±0.16	0.39±0.17
外髓质面积/肾脏面积 Area of outer medulla/kidney	0.22±0.08	0.22±0.07	0.24±0.07	0.23±0.07
肾单位密度 Nephron density	8.82±1.80	6.65±2.86^*	4.73±1.13^#	6.61±2.61
皮质肾小球数量 Number of cortical glomeruli	34.40±8.80	29.80±5.07	31.7±6.15	31.66±6.72
外髓质肾小球数量 Number of extramedullary glomeruli	42.10±8.79	37.37±9.60	44.03±8.54	41.05±9.38
皮质肾小球长度 Length of cortical glomerulus	57.70±5.96	67.06±8.74^*	82.38±18.35^#	69.04±15.84
外髓质肾小球长度 Length of extramedullary glomerulus	86.81±8.94	91.45±13.74^*	110.58±14.18^#	96.39±16.16
皮质部近曲小管数/远曲小管数 PCT/DCT in cortex	2.31±0.94	2.25±1.02	3.58±1.63	2.70±1.35
近髓部近曲小管数/远曲小管数 PCT/DCT in proximal medulla	3.12±2.19	4.24±2.78	2.23±0.79	3.15±2.16

测量指标 Measurement index	2月龄 2 months old	6月龄 6 months old	12月龄 12 months old	合计 Total
髓质厚度/皮质厚度 Thickness of medulla/cortex	3.99±1.34	3.82±0.68	3.36±0.97	3.61±1.20
外髓质厚度/皮质厚度 Thickness of outer medulla/cortex	0.91±0.24	0.95±0.16	0.84±0.33	0.90±0.25
内髓质面积/皮质面积 Area of internal medulla/cortex	0.30±0.10	0.26±0.09	0.35±0.37	0.31±0.24
内髓质面积/肾脏面积 Area of internal medulla/kidney	0.17±0.04	0.16±0.04	0.17±0.11	0.17±0.07
髓质面积/皮质面积 Area of medulla/cortex	0.68±0.28	0.64±0.25	0.78±0.43	0.70±0.33
外髓质面积/皮质面积 Area of outer medulla/cortex	0.38±0.19	0.38±0.17	0.42±0.16	0.39±0.17
外髓质面积/肾脏面积 Area of outer medulla/kidney	0.22±0.08	0.22±0.07	0.24±0.07	0.23±0.07
肾单位密度 Nephron density	8.82±1.80	6.65±2.86^*	4.73±1.13^#	6.61±2.61
皮质肾小球数量 Number of cortical glomeruli	34.40±8.80	29.80±5.07	31.7±6.15	31.66±6.72
外髓质肾小球数量 Number of extramedullary glomeruli	42.10±8.79	37.37±9.60	44.03±8.54	41.05±9.38
皮质肾小球长度 Length of cortical glomerulus	57.70±5.96	67.06±8.74^*	82.38±18.35^#	69.04±15.84
外髓质肾小球长度 Length of extramedullary glomerulus	86.81±8.94	91.45±13.74^*	110.58±14.18^#	96.39±16.16
皮质部近曲小管数/远曲小管数 PCT/DCT in cortex	2.31±0.94	2.25±1.02	3.58±1.63	2.70±1.35
近髓部近曲小管数/远曲小管数 PCT/DCT in proximal medulla	3.12±2.19	4.24±2.78	2.23±0.79	3.15±2.16

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