Research Progress on Mechanism and Intervention of Renal Function Injury in Hyperlipidemia Animal Model

doi:10.12300/j.issn.1674-5817.2021.116

Abstract

Abstract:

Hyperlipidemia is closely related to renal function damage, and they influence each other. Lipid deposition in the kidney affects the function and structure of glomerulus and renal tubules directly and indirectly, resulting in renal function injury. On the contrary, renal function damage further affects lipid metabolism and aggravates the progress of hyperlipidemia. At present, besides synthetic drugs, there are many non-synthetic drugs which have been well verified in the intervention of kidney injury in hyperlipidemia animal model. In this paper, the research progress in the mechanism of renal function damage and the related intervention using hyperlipidemia animal model at home and abroad in recent years were summarized.

Key words: Hyperlipidemia, Kidney injury, Animal model

CLC Number:

Q95-33

Xiaoli ZHOU,Qian ZHANG,Zhiyong QIAN. Research Progress on Mechanism and Intervention of Renal Function Injury in Hyperlipidemia Animal Model[J]. Laboratory Animal and Comparative Medicine, 2022, 42(3): 213-219. DOI: 10.12300/j.issn.1674-5817.2021.116.

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