Mammary Gland Hyperplasiain Model in Male Mongolian Gerbil Induced by Estradiol

doi:10.3969/j.issn.1674-5817.2017.05.003

Abstract

Abstract: Objective To establish mammary gland hyperplasia model in male Mongolian gerbil induced by estradiol. Methods The male Mongolian gerbils, mouse and rats were respectively ip estradiol benzoate to establish mammary gland hyperplasia model. Observe and compare the mammary gland of the experimental group with the control group. Results Histological observation showed that the mammary gland was not found in the normal male gerbils, and mammary ductal and glandular lobes were found in the male gerbils induced by estrogen. In addition, compared with mouse and rats, the gerbils showed mammary gland hyperplasia with inflammatory cells infiltration. Conclusions The mammary gland hyperplasia was successful replicated in mouse, rats and gerbils induced by estradiol benzoate, and initially demonstrated that Mongolian gerbil can be used as male mammary gland hyperplasia animal model.

Key words: Mongolian gerbil, Estradiol, Gynecomastia

CLC Number:

Q95-33

WANG Cun-long, DU Xiao-yan, LIU Xin, GUO Meng, LV Jian-yi, CHEN Zhen-wen, LI Chang-long. Mammary Gland Hyperplasiain Model in Male Mongolian Gerbil Induced by Estradiol[J]. Laboratory Animal and Comparative Medicine, 2017, 37(5): 352-356.

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