Progress in Animal Models of Secondary Lymphedema

doi:10.12300/j.issn.1674-5817.2021.081

Abstract

Abstract:

Secondary lymphedema (SL) seriously affects the physiological and psychosocial status of cancer patients. The establishment of appropriate animal models for basic research is crucial to study the pathogenesis and treatment of SL. At present, there are many animal models of SL, but the lack of uniformity results in slow progress of mechanism research. Based on the research progress of SL animal models, this paper analyzes the types of experimental animals and the intervention methods of modeling in SL research. The analysis results showed that rodents (especially rats) are ideal experimental animals, and a stable and durable chronic SL model can be prepared by combining surgery with two times of preoperative and postoperative radiation, which has been confirmed in daily scientific research work.

Key words: Secondary lymphedema, Animal model, Radiation, Surgery

CLC Number:

Q95-33

Xing YANG, Xingfang PAN, Tianyi ZHAO, Meidan ZHAO, Zhongzheng LI. Progress in Animal Models of Secondary Lymphedema[J]. Laboratory Animal and Comparative Medicine, 2022, 42(1): 62-67.

Figures/Tables 2

References 35

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文献来源	动物	方式	部位	手术操作	持续时间
Hassanein等^[11](2021)	小鼠	手术	尾部	全层切除和淋巴管夹断	超过15 d
Weiler等^[12](2019)	小鼠	手术	尾部	单血管结扎	70 d
Randolfo等^[23](2018)	兔	手术	耳部	全皮肤剥脱和破坏淋巴通道	15 d
Tobbia等^[24](2009)	羊	手术	后肢	切除淋巴结，结扎淋巴管	16周

文献来源	动物	方式	部位	手术操作	持续时间
Hassanein等^[11](2021)	小鼠	手术	尾部	全层切除和淋巴管夹断	超过15 d
Weiler等^[12](2019)	小鼠	手术	尾部	单血管结扎	70 d
Randolfo等^[23](2018)	兔	手术	耳部	全皮肤剥脱和破坏淋巴通道	15 d
Tobbia等^[24](2009)	羊	手术	后肢	切除淋巴结，结扎淋巴管	16周

文献来源	动物种类	方式	部位	手术操作	放射剂量	持续时间
Harb等^[8](2020)	大鼠	手术和放射	后肢	腹股沟淋巴结切除术、圆周皮肤和皮下组织切除术	22.7 Gy/40.5 Gy	未报告
Triacca等^[10](2019)	大鼠	手术和放射	后肢	手术切除腘窝和腹股沟淋巴结	22.7 Gy	至少8周
Sommer等^[21](2012)	大鼠	手术和放射	后肢	切除体表腹股沟和腘窝淋巴结及邻近淋巴管	15 Gy	未报告
孙一宇，等^[29](2016)	小鼠	手术和放射	后肢	摘除腘窝淋巴结，结扎淋巴管，烧灼皮肤	4.5 Gy	24周
吴国君^[34](2017)	猕猴	手术和放射	上肢	腋窝淋巴结清扫术	30 Gy	12个月
柴凡，等^[32](2011)	兔	手术和放射	前肢	切除右侧腋窝、胸肌外缘及锁骨下淋巴结，破坏淋巴管	15 Gy	18周

文献来源	动物种类	方式	部位	手术操作	放射剂量	持续时间
Harb等^[8](2020)	大鼠	手术和放射	后肢	腹股沟淋巴结切除术、圆周皮肤和皮下组织切除术	22.7 Gy/40.5 Gy	未报告
Triacca等^[10](2019)	大鼠	手术和放射	后肢	手术切除腘窝和腹股沟淋巴结	22.7 Gy	至少8周
Sommer等^[21](2012)	大鼠	手术和放射	后肢	切除体表腹股沟和腘窝淋巴结及邻近淋巴管	15 Gy	未报告
孙一宇，等^[29](2016)	小鼠	手术和放射	后肢	摘除腘窝淋巴结，结扎淋巴管，烧灼皮肤	4.5 Gy	24周
吴国君^[34](2017)	猕猴	手术和放射	上肢	腋窝淋巴结清扫术	30 Gy	12个月
柴凡，等^[32](2011)	兔	手术和放射	前肢	切除右侧腋窝、胸肌外缘及锁骨下淋巴结，破坏淋巴管	15 Gy	18周

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