实验动物与比较医学 ›› 2018, Vol. 38 ›› Issue (2): 160-164.DOI: 10.3969/j.issn.1674-5817.2018.02.016

• 综述 • 上一篇    

鼠痘病毒感染机制及其检测方法研究进展

周洁, 赵丽娟, 陶凌云, 胡建华, 高诚   

  1. 上海实验动物研究中心,上海 201203
  • 收稿日期:2017-08-17 出版日期:2018-04-25 发布日期:2018-04-25
  • 作者简介:周洁(1978-),女,博士,研究员,主要从事动物病毒分子生物学及免疫学方面的研究。E-mail:zhoujie0526@163.com
  • 基金资助:
    上海市科委科技创新行动计划(15140900800);上海市科委研发平台专项(15DZ22924000)

Research Progress on Infection Mechanism and Diagnostic Methods of Ectromelia Virus

ZHOU Jie, ZHAO Li-juan, TAO Ling-yun, HU Jian-hua, GAO Cheng   

  1. Shanghai Laboratory Animal Research Center,Shanghai,201203 China
  • Received:2017-08-17 Online:2018-04-25 Published:2018-04-25

摘要: 概述了鼠痘病毒(ECTV)入侵动物机体后感染传播的机制,包括小鼠的天然抗病机理、机体免疫应答以及病毒感染的致病机理等。同时总结了检测ECTV的试验动物法、病理学方法、血清学方法和核酸诊断方法等的优缺点。通过系统了解ECTV的感染途径和诊断方法,有助于防控ECTV的发生及传播。

关键词: 鼠痘病毒(ECTV), 感染机制, 免疫应答, 检测

Abstract: The paper mainly reviewed the infection and spread mechanisms of Ectromelia virus (ECTV) in animals,including natural disease resistance mechanism of the mice,the body's immune response and pathogenic mechanism of virus infection.Furthermore,we described the animal experiments,pathological diagnosis,serological methods,nucleic acid methods of ECTV and their advantages and disadvantages.This article can help to understand infection mechanism and different diagnostic methods of ECTV,which may contribute to control the spread of ECTV.

Key words: Ectromelia virus (ECTV), Infection mechanism, Immune response, Detection

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