骨性关节炎动物模型研究进展

doi:10.3969/j.issn.1674-5817.2020.02.013

摘要/Abstract

摘要： 骨性关节炎(OA)动物造模方式繁多,国内外众多学者针对其发病特点,利用不同种类的动物进行造模。各造模方案不同,其动物模型特点亦不同。本文从原发性OA和继发性OA两点入手,以转基因模型和实验诱导模型为主要切入点进行整理,并分析其优缺点,以期对OA的发病机制、疾病发展变化、过程、转归以及相关的科学研究有所帮助。

关键词: 骨性关节炎, 动物模型, 综述

Abstract: There are plenty of animal models of osteoarthritis (OA). Researchers all over the world are trying to identify different pathogenic characteristics with different animal models. Focusing on primary OA and posttraumatic OA, this paper utilizes the genetically modified models and the experimental induction models to analyze their advantages and disadvantages, to support the research of the pathogenesis, the change and the process, and the outcomes of OA.

Key words: Osteoarthritis, Animal Models, Review

中图分类号:

R-274
Q95-33

夏梦熊, 韩海慧, 梁倩倩, 翟伟韬, 徐浩. 骨性关节炎动物模型研究进展[J]. 实验动物与比较医学, 2020, 40(2): 159-165.

XIA Mengxiong, HAN Haihui, LIANG Qianqian, ZHAI Weitao, XU Hao. Research Progress on Animal Models of Osteoarthritis[J]. Laboratory Animal and Comparative Medicine, 2020, 40(2): 159-165.

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