关键词: 心脏移植, 大鼠, 动物模型

Abstract: Objective To establish a quick and effective heterotopic heart transplantation model in rat. Method Male SD rats served as donors and Wistar as recipients,the ascending aorta of allograft was anastomosed to the recipient abdominal aorta, the recipient underwent a left nephrectomy, and the right pulmonary artery of allograft inserted into the left renal vein of donors. Results The mean ischemic time was (37.8 ±1.8) min in 35 experiments. The successful rate was 91.4%. Complications were anastomotic orificces hemorrhange, thrombosis. Conclusion This method has advantage of simpleness, and requiring no operating microscope. So it is easily to be applied.

Key words: Heart transplantation, Rats, Animal models