实验动物与比较医学 ›› 2001, Vol. 21 ›› Issue (2): 79-81.
• 论文 •
基金资助:
国家科技部基金项目（特别资助）
摘要： 用HPLC-ECD法对APP695，751V717I转基因模型小鼠大脑皮层神经递质进行检测，结果显示APP751转基因鼠大脑皮层中的5-HIAA含量与对照组比较有显著性差异。APP695转基因鼠大脑皮层中DA和5-HT平均含量分别比对照鼠升高38.9%和45.8%。提示Aβ的形成可能影响了多巴胺系统和5-羟色胺系统。
Abstract: Alzheimer's disease(AD)is a progressive meurodegenerative disease. It is dnown that AD is associated with some neuotransmitters disorder. We examine the monoamine transmitter in neuons of forebrain by HPLC-ECD method. The content of the 5-HIAA in APP amyloid precursor prorein 751 trangenic micc show significant difference compared with that of the control group. The content of the DA and 5-HT in APP695 transgenic mice increased 38.9% and 45.8% respectively compared with control group. It suggested that the DA and 5-HT system may be affected respectively by Aβ
. The Changes of Monoamine Transmitter in Mutant Amyloid Precursor Protein Transgenic Mouse Brain[J]. Laboratory Animal and Comparative Medicine, 2001, 21(2): 79-81.
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https://www.slarc.org.cn/dwyx/CN/Y2001/V21/I2/79
