Abstract: Objective To compare the ratio of the incomplete circle of Willis patterns and detect the blood biochemical and physiological indexes of 2 ischemia-prone inbred gerbil lines CMU/1 and CMU/2, and to analyze the differences between 2 strains, provide reference data for gerbils experimental application. Methods Beckman automatic biochemical analyzer (CX5) and Japan photoelectric automatic blood cell analyzer (MEK-7222K) were used to determine 17 blood biochemical parameters and 22 physiological parameters. SPSS 23.0 software was used for statistical analysis by independent samples T test. Results The ratios of incomplete circle of Willis patterns in both ischemia-prone inbred gerbil lines CMU/1 and CMU/2 were more than 76%. The 12 parameters of blood physiology and biochemistry, glucose, creatinine, triglycerides, cholesterol, platelet, mean platelet volume, basophilic granulocyte, lymphocyte%, platelet distribution width, hematocrit, mean corpuscular volume, mean Corpuscular hemoglobin, were significantly different between male and female. CMU/1 and CMU/2 were significantly different in female alanine transaminase, platelet and platelet distribution width, and high-density lipoprotein cholesterol and mean corpuscular hemoglobin in males were significantly different. There were significant differences in alkaline phosphatase, alanine transaminase and aspartate transaminase between strains. Conclusion The genotypes of ischemia-prone inbred gerbil have some impact on blood biochemical and physiological parameters.

Key words: Gerbil, Inbred strain, Ischemia model, Biochemical index, Physiological index