Laboratory Animal and Comparative Medicine ›› 2018, Vol. 38 ›› Issue (1): 57-59.DOI: 10.3969/j.issn.1674-5817.2018.01.011

Special Issue: 实验动物资源开发与利用

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Comparison of Four Blood Coagulation Factors among Gerbil CMU/1,Gerbil CMU/2 and F344 Rat and BALB/c Mouse

LI Ying1,3, DU Xiao-yan2, CUI Xiao-xia1, MA Lan-zhi1, SHANG Shi-chen1, ZHAO Zhi-Bing1, ZHAO Quan3, LI Gui-jun1, WANG Dong-ping1, CHEN Zhen-wen2   

  1. 1. Laboratory Animal Center,Military Medical Sciences,Military Academy,Beijing 100071,China;
    2. Department of Laboratory Animal Science,Capital Medical University,Beijing 100069,China;
    3. College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China
  • Received:2017-08-10 Online:2018-02-25 Published:2021-03-01

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Abstract: Objective To detect and compare the differences of coagulation factors between inbred gerbil CMU/1 and CMU/2,inbred rat F344,and inbred mouse BALB/c;then to analyze the characteristics of inbred ischemia-prone gerbil.Methods The four channel blood coagulation analyzer was used to determine three kinds of inbred animals’plasma prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB),and thrombin time (TT).The SPSS23.0 software was applied for statistical analysis of data.Results The APTT FIB of CMU/1 and the FIB of CMU/2 of ischemia-prone gerbil displayed high standard deviation.The PT and FIB of CMU/1 and CMU/2 showed significantly different compared with that of F344 rat.The APTT of both ischemia-prone inbred gerbil lines demonstrated significant difference compared with BALB/c mouse and F344 rat.Conclusion The 4 coagulation factors of ischemia-prone inbred gerbil lines are consistent with those of inbred BALB/c mouse;which are significantly different from those of inbred F344 rat.

Key words: Ischemia model, Gerbil, Inbred lines, Coagulation factors, F344 rat, BALB/c mouse

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