Abstract: Objective To understand the differences on physiological indexes of single caged and social group female macaca fascicularis. Methods Nine female cynomolgus monkeys at the age of 4-6 years old were singly raised in cage at the first 5 months,and group raised in next 5 months.The body weight, body temperature, blood routine, urine routine, blood biochemistry were measured in single caged rearing and group breeding, repeated measures analysis of variance was used to compare whether there were differences between the two stages. Results Body weight in single caged stage was significantly lower than that in group phase (P<0.05). In blood routine, white blood cell count (WBC), neutrophil count (NEUT), neutrophil percentage (NEUT%) in single caged stage were significantly higher than that in group stage (P<0.01); monocyte count (MONO), the percentage of mononuclear cells (MONO%) in single caged stage were significantly lower than that in group stage (P<0.01); lymphocyte percentage(LYMPH%) in single caged stage was significantly lower than that in group stage (P<0.05). In blood biochemistry, total bilirubin(TBIL) in single caged stage was significantly lower than that in group stage (P<0.01); aspartic acid amino transferase (AST), triglyceride (TG) in single caged stage were significantly higher than that in group stage (P<0.05). The positive rate of urine protein in single caged stage is higher than that in the group stage(P<0.05). Other indexes between the groups had no statistical difference. Conclusion The macaca fascicularis was more suitable for the breeding of group, if the long-term single caged feeding, it could have a greater impact on body weight, hematology and urine routine of some indicators.

Key words: Macaca fascicularis, Female, Physiological index, Hematology, Urine routine