Classification and Research Progress on Dendritic Cell Subsets in Mice

doi:10.12300/j.issn.1674-5817.2020.052

Abstract

Abstract: Mouse, a representative rodent laboratory animal, has always been a powerful tool for studying dendritic cell (DC) systems. Our current knowledge of DCs has been largely derived from studies of murine models, and according to surface markers, cell development, and migratory characteristics, DCs can be categorized with respect to their subsets. To date, there is no uniform classification scheme for mouse DC subsets, which has greatly hindered research involving DCs. Thus, we believe that basic studies to define murine DC subsets are still needed, and it is crucial to seek scientific, effective, and recognized methods to establish categorical definitions. This review proposed a schema incorporating the classification, phenotypes, and characteristics of murine DC subsets, and compares them with human DC counterparts. The aim is to clarify the classification and characteristics of the current status of DC subsets in mice and summarize the existing challenges. This would be beneficial for gaining an in-depth understanding of the function of DC subsets and would provide novel research directions for DC subset categorizations.

Key words: Dendritic cells, Cell subsets, Classification, Mice

CLC Number:

R-332
Q95-33

RUAN Leiying,SUN Xiaomei. Classification and Research Progress on Dendritic Cell Subsets in Mice[J]. Laboratory Animal and Comparative Medicine, 2021, 41(2): 174-180. DOI: 10.12300/j.issn.1674-5817.2020.052.

References

[1] WAISMAN A, LUKAS D, CLAUSEN B E, et al.Dendritic cells as gatekeepers of tolerance[J]. Semin Immunopathol, 2017, 39(2): 153-163. DOI.10.1007/s00281-016-0583-z.
[2] SEGURA E.Review of mouse and human dendritic cell subsets[J]. Methods Mol Biol, 2016, 1423:3-15. DOI:10.1007/978-1-4939-3606-9_1.
[3] SCHRAML BU, REIS E SOUSA C. Defining dendritic cells[J]. Curr Opin Immunol, 2015, 32: 13-20. DOI.0.1016/j.coi.2014.11.001.
[4] RODRIGUES P F, ALBERTI-SERVERA L, EREMIN A, et al.Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells[J]. Nat Immunol, 2018, 19(7):711-722. DOI:10.1038/s41590-018-0136-9.
[5] BRISE OCG, HALDAR M, KRETZER N M, et al.Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells[J]. Cell Rep, 2016, 15(11):2462-2474. DOI:10.1016/j.celrep.2016.05.025.
[6] SICHIEN D, SCOTT C L, MARTENS L, et al.IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively[J]. Immunity, 2016, 45(3):626-640. DOI:10.1016/j.immuni.2016.08.013.
[7] LIN Q, CHAUVISTRE H, COSTA I G, et al.Epigenetic program and transcription factor circuitry of dendritic cell development[J]. Nucleic Acids Res, 2015, 43(20): 9680-9693. DOI.10.1093/nar/gkv1056.
[8] ANDERSON D A, 3RD, MURPHY K M, BRISENO C G. Development, diversity, and function of dendritic cells in mouse and human[J]. Cold Spring Harb Perspect Biol, 2018, 10(11): 1-19. DOI.10.1101/cshperspect.a028613.
[9] HANIFFA M, COLLIN M, GINHOUX F.Ontogeny and functional specialization of dendritic cells in human and mouse[J]. Adv Immunol, 2013, 120:1-49. DOI:10.1016/b978-0-12-417028-5.00001-6.
[10] VU MANH TP, BERTHO N, HOSMALIN A, et al.Investigating evolutionary conservation of dendritic cell subset identity and functions[J]. Front Immunol, 2015, 6: 2601-17. DOI.10.3389/fimmu.2015.00260.
[11] SCHLITZER A, ZHANG W, SONG M, et al.Recent advances in understanding dendritic cell development, classification, and phenotype[J]. F1000Res, 2018, 7:1-9. DOI.10.12688/f1000research.14793.1.
[12] MILLER J C, BROWN B D, SHAY T, et al.Deciphering the transcriptional network of the dendritic cell lineage[J]. Nat Immunol, 2012, 13(9):888-899. DOI:10.1038/ni.2370.
[13] SHAY T, JOJIC V, ZUK O, et al.Conservation and divergence in the transcriptional programs of the human and mouse immune systems[J]. PNAS, 2013, 110(8):2946-2951. DOI:10.1073/pnas.1222738110.
[14] MURPHY K M.Transcriptional control of dendritic cell development[J]. Adv Immunol, 2013, 120:239-267. DOI:10.1016/b978-0-12-417028-5.00009-0.
[15] AMON L, LEHMANN CHK, BARANSKA A, et al.Transcriptional control of dendritic cell development and functions[J]. Int Rev Cell Mol Biol, 2019, 349:55-151. DOI.10.1016/bs.ircmb.2019.10.001
[16] NUTT S L, CHOPIN M.Transcriptional networks driving dendritic cell differentiation and function[J]. Immunity, 2020, 52(6):942-956. DOI:10.1016/j.immuni.2020.05.005.
[17] VILLAR J, SEGURA E.Recent advances towards deciphering human dendritic cell development[J]. Mol Immunol, 2020, 122:109-115. DOI:10.1016/j.molimm.2020.04.004.
[18] DURAI V, MURPHY K M.Functions of murine dendritic cells[J]. Immunity, 2016, 45(4):719-736. DOI:10.1016/j.immuni.2016.10.010.
[19] GUILLIAMS M, GINHOUX F, JAKUBZICK C, et al.Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny[J]. Nat Rev Immunol, 2014, 14(8):571-578. DOI:10.1038/nri3712.
[20] ACHIM K, ARENDT D.Structural evolution of cell types by step-wise assembly of cellular modules[J]. Curr Opin Genet Dev, 2014, 27: 102-108. DOI.10.1016/j.gde.2014.05.001.
[21] ARENDT D.The evolution of cell types in animals: emerging principles from molecular studies[J]. Nat Rev Genet, 2008, 9(11):868-882. DOI:10.1038/nrg2416.
[22] VU MANH T P, ELHMOUZI-YOUNES J, URIEN C, et al. Defining mononuclear phagocyte subset homology across several distant warm-blooded vertebrates through comparative transcriptomics[J]. Front Immunol, 2015, 6:299. DOI:10.3389/fimmu.2015.00299.
[23] GUILLIAMS M, HENRI S, TAMOUTOUNOUR S, et al.From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets[J]. Eur J Immunol, 2010, 40(8): 2089-2094. DOI.10.1002/eji.201040498.
[24] BALAN S, SAXENA M, BHARDWAJ N.Dendritic cell subsets and locations[J]. Int Rev Cell Mol Biol, 2019, 348:1-68. DOI:10.1016/bs.ircmb.2019.07.004.
[25] NAIK SH.Demystifying the development of dendritic cell subtypes, a little[J]. Immunol Cell Biol, 2008, 86(5): 439-452. DOI.10.1038/icb.2008.28
[26] GILLIET M, CAO W, LIU Y J.Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases[J]. Nat Rev Immunol, 2008, 8(8):594-606. DOI:10.1038/nri2358.
[27] LEYLEK R, IDOYAGA J.The versatile plasmacytoid dendritic cell: Function, heterogeneity, and plasticity[J]. Int Rev Cell Mol Biol, 2019, 349:177-211. DOI:10.1016/bs.ircmb.2019.10.002.
[28] WATCHMAKER P B, LAHL K, LEE M, et al.Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice[J]. Nat Immunol, 2014, 15(1):98-108. DOI:10.1038/ni.2768.
[29] MILDNER A, JUNG S.Development and function of dendritic cell subsets[J]. Immunity, 2014, 40(5):642-656. DOI.10.1016 / j.immuni.2014.04.016.
[30] Crozat K, Guiton R, Guilliams M, et al.Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets[J]. Immunol Rev, 2010, 234(1): 177-198. DOI.10.1111/j.0105-2896.2009.00868.x.
[31] ROMANI N, CLAUSEN B E, STOITZNER P.Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin[J]. Immunol Rev, 2010, 234(1):120-141. DOI:10.1111/j.0105-2896.2009.00886.x.
[32] MERAD M, GINHOUX F, COLLIN M.Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells[J]. Nat Rev Immunol, 2008, 8(12): 935-947. DOI.10.1038/nri2455.
[33] DOEBEL T, VOISIN B, NAGAO K.Langerhans cells - the macrophage in dendritic cell clothing[J]. Trends Immunol, 2017, 38(11): 817-828. DOI.10.1016/j.it.2017.06.008.
[34] KAPLAN D H.Ontogeny and function of murine epidermal Langerhans cells[J]. Nat Immunol, 2017, 18(10):1068-1075. DOI:10.1038/ni.3815.
[35] REIZIS B, BUNIN A, GHOSH H S, et al.Plasmacytoid dendritic cells: recent progress and open questions[J]. Annu Rev Immunol, 2011, 29:163-183. DOI:10.1146/annurev-immunol-031210-101345.
[36] KUROTAKI D, KAWASE W, SASAKI H, et al.Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice[J]. Blood, 2019, 133(17):1803-1813. DOI:10.1182/blood-2018-06-857789.
[37] CISSE B, CATON M L, LEHNER M, et al.Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development[J]. Cell, 2008, 135(1):37-48. DOI:10.1016/j.cell.2008.09.016.
[38] ITO T, KANZLER H, DURAMAD O, et al.Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells[J]. Blood, 2006, 107(6):2423-2431. DOI:10.1182/blood-2005-07-2709.
[39] ROBBINS SH, WALZER T, DEMBELE D, et al.Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling[J]. Genome Biol, 2008, 9(1): R171-7. DOI.10.1186/gb-2008-9-1-r17.
[40] STEINMAN R M.Decisions about dendritic cells: past, present, and future[J]. Annu Rev Immunol, 2012, 30:1-22. DOI.10.1146/annurev-immunol-100311-102839.
[41] SCHLITZER A, MCGOVERN N, TEO P, et al.IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses[J]. Immunity, 2013, 38(5): 970-983. DOI.10.1016 / j.immuni.2013.04.011.
[42] POULIN L F, REYAL Y, URONEN-HANSSON H, et al.DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues[J]. Blood, 2012, 119(25):6052-6062. DOI:10.1182/blood-2012-01-406967.
[43] WEIH F, CARRASCO D, DURHAM S K, et al.Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family[J]. Cell, 1995, 80(2):331-340. DOI:10.1016/0092-8674(95)90416-6.
[44] COLLIN M, MCGOVERN N, HANIFFA M.Human dendritic cell subsets[J]. Immunology, 2013, 140(1): 22-30. DOI.10.1111/imm.12888.
[45] SEGURA E, AMIGORENA S.Inflammatory dendritic cells in mice and humans[J]. Trends Immunol, 2013, 34(9):440-445. DOI:10.1016/j.it.2013.06.001.
[46] LEÓN B, LÓPEZ-BRAVO M, ARDAV?N C. Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania[J]. Immunity, 2007, 26(4):519-531. DOI:10.1016/j.immuni.2007.01.017.
[47] GUTTMAN-YASSKY E, LOWES M A, FUENTES-DUCULAN J, et al.Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis[J]. J Allergy Clin Immunol, 2007, 119(5):1210-1217. DOI:10.1016/j.jaci.2007.03.006.
[48] OTSUKA M, EGAWA G, KABASHIMA K.Uncovering the mysteries of Langerhans cells, inflammatory dendritic epidermal cells, and monocyte-derived Langerhans cell-like cells in the epidermis[J]. Front Immunol, 2018, 9:1768. DOI:10.3389/fimmu.2018.01768.
[49] LIU K, VICTORA G D, SCHWICKERT T A, et al.In vivo analysis of dendritic cell development and homeostasis[J]. Science, 2009, 324(5925):392-397. DOI:10.1126/science.1170540.