Classification and Research Progress on Dendritic Cell Subsets in Mice

doi:10.12300/j.issn.1674-5817.2020.052

Abstract

Abstract: Mouse, a representative rodent laboratory animal, has always been a powerful tool for studying dendritic cell (DC) systems. Our current knowledge of DCs has been largely derived from studies of murine models, and according to surface markers, cell development, and migratory characteristics, DCs can be categorized with respect to their subsets. To date, there is no uniform classification scheme for mouse DC subsets, which has greatly hindered research involving DCs. Thus, we believe that basic studies to define murine DC subsets are still needed, and it is crucial to seek scientific, effective, and recognized methods to establish categorical definitions. This review proposed a schema incorporating the classification, phenotypes, and characteristics of murine DC subsets, and compares them with human DC counterparts. The aim is to clarify the classification and characteristics of the current status of DC subsets in mice and summarize the existing challenges. This would be beneficial for gaining an in-depth understanding of the function of DC subsets and would provide novel research directions for DC subset categorizations.

Key words: Dendritic cells, Cell subsets, Classification, Mice

CLC Number:

R-332
Q95-33

RUAN Leiying, SUN Xiaomei. Classification and Research Progress on Dendritic Cell Subsets in Mice[J]. Laboratory Animal and Comparative Medicine, 2021, 41(2): 174-180.

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