Advantages and Challenges of Tree Shrews in Biomedical Research

doi:10.3969/j.issn.1674-5817.2019.01.002

Abstract

Abstract: Animal model is an important method to study the mechanism of human disease, to screen drug, and to evaluate the safety and efficacy of drugs. With the development of molecular biology technology and the study of molecular genetic mechanism of human diseases, it is difficult to study the complex symptoms of human diseases in biomedical research using rodents as a result of the differences in genetic background, physiological and metabolic characteristics between rodent and human, the limitation of rodent in life science research is increasingly prominent. Primates play an irreplaceable role in biomedical research due to its evolution and biological characteristics. However, the limitation of genetic manipulation, long breeding cycle and high cost restrict the application of primates in biomedical research. The evolution of tree shrews are more closer to the primate than rodents. Tree shrews has been increasingly applied in the field of biomedical research since its characteristics of easy breeding, fast reproduction, the low cost and the key factors of neurological dysfunction and infectious diseases are conservative compared with primates. Based on the characteristics of physiological metabolic process and anatomical structure of tree shrews, this paper analyzes the advantages and problems of tree shrew in biomedical research.

Key words: Tree shrew, Animal model, Biomedicine

CLC Number:

Q95-33

JIA Jie, DAI Jie-jie. Advantages and Challenges of Tree Shrews in Biomedical Research[J]. Laboratory Animal and Comparative Medicine, 2019, 39(1): 3-8.

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