Research Progress of Murine Norovirus in Characteristics, Immunology and Detection Methods

doi:10.3969/j.issn.1674-5817.2015.05.016

Abstract

Abstract: Murine norovirus (MNV) is the only norovirus that can be cultivated in vitro. The isolation of the strains and its successful proliferation in the mouse macrophage RAW264.7 cell lay the foundation for molecular mechanism research of norovirus, which also provide help for the pathogenic mechanism research and preparation of vaccine of human norovirus (HuNoVs). MNV is one of the most widely spread infection factors in mice. The replication of murine norovirus in cell culture reveals a tropism for dendritic cells and macrophages. The virus can make lethal effect on immune-deficient mice. It's of great significance to strengthen the control of the virus infection.

Key words: Murine norovirus, Characteristics, Mechanism, Detection

CLC Number:

Q95-33

GAO Jie, HE Zheng-ming. Research Progress of Murine Norovirus in Characteristics, Immunology and Detection Methods[J]. Laboratory Animal and Comparative Medicine, 2015, 35(5): 414-420.

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