Research Progress on Autophagy with Parkinson Disease and Related Models

doi:10.3969/j.issn.1674-5817.2015.04.020

Abstract

Abstract: Parkinson disease (PD) is a common neurodegeneration disease, it has seriously affect on quality of life in elder. At present the pathogenesis of PD is unclear, environmental and genetic factors are closely related with it. An increasing number of evidences suggest that mitochondrial dysfunction and autophagy damage may be one of the key molecular mechanisms leading to the onset of PD, thus it would be significant to study the role of autophagy in the pathogenesis of PD by using cellular models and PD animal models. The paper briefly review the research progress of mitochondrial autophagy correlation with Parkinson's disease.

Key words: Autophagy, Mitochondria, Parkinson disease(PD), Model

CLC Number:

Q95-33

LI Yuan, ZHANG Mei-ying. Research Progress on Autophagy with Parkinson Disease and Related Models[J]. Laboratory Animal and Comparative Medicine, 2015, 35(4): 335-340.

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