Comparison on Micro- and Ultrastructure of Kidney between Naked Mole Rats and C57BL/6J Mice

doi:10.3969/j.issn.1674-5817.2013.05.014

Abstract

Abstract: Objective To compare the microstructure and ultrastructure of kidney between naked mole rat(NMR, a new type of laboratory animal) and C57BL/6J mouse(a commonly used laboratory animal). Method s The kidney were taken from NMR and C57BL/6J mice , and the specimens were made for microscopic and electron microscopic(SEM) observation. Results Compared with C57BL/6J, the renal tubular epithelium of NMR is thinner, and there are also multiple pathological calcifications inside the cortex and medulla of kidney. The mitochondrion inside renal tubular epithelial cells appear to expand and even degrade, with the apparent expansion of endoplasmic reticulum. Conclusion Remarkable differences exist in the kidney tissue between NMR and C57BL/6J, there is gradual pathological damages in the renal tubular epithelial cells of NMR who in the meanwhile has the strong ability of self-reparation.

Key words: Naked mole rat, C57BL/6J mouse, Microstructure, Ultrastructure, Comparative study

CLC Number:

Q95-33

ZHANG Lu, ZHAO Yi-ning, YUAN Zi-yan, ZHAO Shan-min, LIN Li-fang, TANG Qiu, Sun Wei, YU Chen-ling, CAI Li-ping, XU Chen, CUI Shu-fang. Comparison on Micro- and Ultrastructure of Kidney between Naked Mole Rats and C57BL/6J Mice[J]. Laboratory Animal and Comparative Medicine, 2013, 33(5): 388-394.

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