Abstract: Objective To study the percutaneous absorption of terbinafine hydrochloride cream through in vitro Tibet minipig’s skins, and compare the penetration absorption of domestic certain enterprise product with GlaxoSmithKline china product. Methods Using the modified Franz diffusion cell, samples were collected at different time after the drug was applied. The concentration of terbinafine hydrochloride in the samples was measured by HPLC. Results The penetration release quantities of terbinafine hydrochloride across Tibet minipig skins in 80% ethanol saline solution in 48h were very low, only 63.33 µg·cm^-2 for GlaxoSmithKline China product, and 55.23 µg·cm^{- 2} for certain enterprise product, and the percolation rate were 1.19% and 1.09%, respectively. Conclusion The percutaneous absorption of terbinafine hydrochloride cream was very low between two products without significant difference. The penetration absorbency through Tibet minipig skins of certain enterprise cream is similar to GlaxoSmithKline china product. The most of the main components of terbinafine hydrochloride cream remain in the surface of the skins, only a few through the skin barrier. It was more suited to local cure.

Key words: Terbinafine hydrochloride, Cream, Percutaneous absorption, Tibet minipig, in vitro