Evaluations on Rat Model of Tibia Cancer Pain with Bone Mineral Density

doi:10.3969/j.issn.1674-5817.2012.04.007

Abstract

Abstract: Objective To evaluate the rat tibia cancer pain model with bone mineral density by iconography. Method Thirty six female Sprague-Dawley (SD) rats were randomly divided into a control group and two model groups with 12 rats in each. Rats from model groups were received intra-tibia injection of syngeneic Walker 256 rat mammary gland carcinoma cells. Series of tests were carried out including spontaneous pain score, mechanical stimuli pain hypersensitivity test, X-ray imaging, bone mineral density test and histopathology observation. Result Bone mineral density test could make the difference between each group, and the result of BMD test was the same as other tests. Conclusion Bone mineral density (BMD) can be used to evaluate rat tibia cancer pain model.

Key words: Tibia cancer pain model, Rat, Walker 256, Bone mineral density (BMD)

CLC Number:

Q95-33

MIAO Jian-cheng, ZHAO Ying, CHEN Guo-qiang, ZHAO Li-ya, JIN Yi, LIU Da-hai, QIAO Wei-wei, ZHAO Xian-zhe. Evaluations on Rat Model of Tibia Cancer Pain with Bone Mineral Density[J]. Laboratory Animal and Comparative Medicine, 2012, 32(4): 290-294.

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