Abstract: Objective To study the effect of mental stress on the alopecia areata incidence in C3H/HeJ mice. Methods Eighty C3H/HeJ mice were selected and randomly divided into 4 groups: mental stress group, drug-induced group, mental stress and drug-induced group, and control group, each group including 20 mice. Follow-up a period and observe the incidence of alopecia areata after intervention, and compare the differences among groups. Results The alopecia areata incidence of mental stress group was 10%, the control group did not occur; the incidence of mental stress and drug-induced group was 90%, incidence of drug-induced group was 60%, the difference was statistically significant (P<0.05). Conclusion The mental stress significantly increased the alopecia areata incidence of C3H/HeJ mouse.

Key words: Mental stress, C3H/HeJ mouse, Alopecia areata