实验动物与比较医学 ›› 2019, Vol. 39 ›› Issue (4): 319-322.DOI: 10.3969/j.issn.1674-5817.2019.04.012

• 经验交流 • 上一篇    下一篇

优化硫酸钡造影剂对小鼠血管造影效果观察

钱凤涛, 王成稷, 王恺, 李珺, 赵轶芸, 袁益婷, 缪祥   

  1. 中国科学院上海营养与健康研究所, 上海 200031
  • 收稿日期:2019-03-13 出版日期:2019-08-25 发布日期:2021-01-31
  • 作者简介:钱凤涛(1981-),女,实验师,从事实验动物专业。E-mail:ftqian@sibs.ac.cn;王成稷(1989-),男,助理实验师,从事实验动物专业。E-mail:cjwang@sibs.ac.cn

Study on Angiography in Mice with Barium Sulfate

QIAN Feng-tao, WANG Cheng-ji, WANG Kai, LI Jun, ZHAO Yi-yun, YUAN Yi-ting   

  1. Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200231, China
  • Received:2019-03-13 Online:2019-08-25 Published:2021-01-31

摘要: 目的 优化硫酸钡造影剂的配方,并尝试对小鼠血管造影。方法 使用不同配比的免洗手消毒凝胶-生理盐水-硫酸钡造影剂混悬液对小鼠动脉血管造影,对成像结果进行对比。结果 在反复测试后得出硫酸钡混悬液最佳配方为: 硫酸钡4 g,免洗手消毒凝胶1 mL,生理盐水5 mL,温度25 ℃,灌注量为0.5~0.8 mL/25 g。结论 经优化后的硫酸钡造影剂可用于小鼠血管造影并能得到很好效果。

关键词: 硫酸钡, 血管造影, 小鼠

Abstract: Objective To optimize the formulation of barium sulfate contrast agent and try to perform angiography in mice. Methods The arterial angiography of mice was performed with different ratios of hand-free disinfection gel-saline-barium sulfate contrast agent , and the imaging results were compared. Results After repeated tests, the optimum formula of barium sulfate suspension was obtained as follows: barium sulfate 4 g, hand disinfecting gel 1 mL, and saline 5 mL, with temperature 25 ℃ and perfusion volume 0.5~0.8 mL/25 g. Conclusion The optimized barium sulfate contrast agent can be used in mouse angiography and can obtain good results.

Key words: Barium Sulfate, Angiography, Mouse

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