›› 1994, Vol. 14 ›› Issue (1): 14-16.

• 论文 • 上一篇    下一篇

内毒素致热兔血浆、脑脊液、隔区和下丘脑中精氨酸加压素含量的变化

  

  1. 中国人民解放军兰州医学高等专科学校
  • 收稿日期:1993-06-07 出版日期:1994-01-25 发布日期:1994-01-25

Changes of A VP Contents in Plasma,CSF,Septal Area and Hypothalamus of Rabbits During Endotoxin Fever

  1. Department of Physiology,Lanzhou Military Medical College of PL A, Lanzhou 730020
  • Received:1993-06-07 Online:1994-01-25 Published:1994-01-25

摘要: 观察了青紫蓝兔内毒素(ET)性发热时血浆、脑脊液(CSF)、隔区和下丘脑精氨酸加压素(AVP)含量的变化。兔ivET10ng/kg后90min,最大升温效应为1.0±0.36℃(n=9)。与对照组比较,其血浆和CSF中AVP含量均明显降低,隔区AVP含量无明显变化,而下丘脑AVP含量则明显升高。结果提示,家兔发热时能促进下丘脑AVP的合成及分泌,使隔区的AVP含量不减少;也提示发热时血浆和CSF中AVP含量降低,并非下丘脑分泌减少所致,可能与发热时释放入CSF中的AVP减少或消耗增多有关。

关键词: 内毒素性发热, 精氨酸加压素, 兔, 血浆, 脑脊液, 隔区, 下丘脑

Abstract: The changes of arginine vasopressin (AVP) contents in the plasma, cerebrospinal fluid (CSF),septal area and hypothalamus of rabbits during endotoxin fever were observed. At the 90 th minute after treatment with endotoxin (10 ng/kg,iv) the temperatures of the treated rabbits rised 1.00±0.36℃(n = 9),the A VP contents decreased markedly in plasma and CSF,increased markedly in hypothalamus and remained unchanged in septal area of the febrile rabbits as compared with the control animals.The results suggested that endotoxin fever might promote the synthesis and release of AVP in hypothalamus of rabbit.

Key words: Endotoxin fever, Arginine vasopressin, Rabbit