西藏小型猪和五指山小型猪的生理特点及其动脉粥样硬化的发病特征比较研究

doi:10.3969/j.issn.1674-5817.2018.05.001

摘要/Abstract

摘要： 动脉粥样硬化(atherosclerosis,AS)是冠心病和脑卒中发生的主要病因。人类AS的发病模式多种多样,在高血脂环境下,有肥胖导致胰岛素抵抗、共同促进AS形成,也有胰岛素抵抗导致高血压、加速AS形成,往往同时存在代谢综合征的一种或多种临床表象,其发生与发展是遗传因素和环境因素共同作用的结果。猪在循环系统、血小板凝聚系统、脂蛋白代谢及消化系统均与人类极为相似,其AS病变与人类AS病变的分布特点相一致,并具有人类成熟斑块的特点,是研究AS的一个重要模式动物。我国小型猪种质资源丰富,不同品种品系的小型猪具有不同种质特性和生物学功能。五指山小型猪、西藏小型猪尤如人类的两个不同类型的AS易感群体。本文就作者研究团队对五指山小型猪、西藏小型猪的AS形成和病症特点方面的研究作一回顾性的总结,为在心血管疾病研究中对小型猪品系的选择和应用提供一些参考。

关键词: 西藏小型猪, 五指山小型猪, 动脉粥样硬化(AS), 生理特点, 发病特征

中图分类号:

Q95-33

陈民利. 西藏小型猪和五指山小型猪的生理特点及其动脉粥样硬化的发病特征比较研究[J]. 实验动物与比较医学, 2018, 38(5): 325-328.

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