关键词: 不同剂量辐射, X射线, 外周血细胞, 小鼠

Abstract: Objective To explore the effects of the different dosages irradiation of X-ray on immune system in mice. Method A total of 192 mice, which were randomly divided into 6 groups: the normal control group, single irradiated experimental groups with the radiation dosages of 2.0 Gy, 3.0 Gy, 4.0 Gy, 5.0 Gy, 6.0 Gy respectively, irradiated by linear accelerator. 24 h, 48 h, 96 h, 192 h after irradiation, blood samples were taken from 8 mice of each group for detection of red blood cells (RBC), white blood cells (WBC), platelets (PLT) and hemoglobins (HGB). Results Compared with the control group, the content of RBC decreased in the different sampling time point. The content of WBC had significant decreased, during the same detecting time, the radiation dosage and the reduction extent of the content of WBC show a positive correlation. The content of PLT decreased, with a positive correlation between the radiation dosage and reduction extent. During different measuring time of each experimental group, the content of HGB decreased with the extension of time. Conclusion There are different changing rules of contents among different peripheral blood cells after radiation, radiation had great influence on the content of WBC, while had no significant influence on other peripheral blood cells.

Key words: Different dose of radiation, X-ray, Peripheral blood cell, Mice