深低温体外循环方法对肺功能影响的实验研究

›› 2001, Vol. 21 ›› Issue (1): 13-16.

深低温体外循环方法对肺功能影响的实验研究

上海第二医科大学附属上海儿童医学中心胸外科,上海 200127；上海第二医科大学附属新华医院小儿心胸外科,上海 200092

收稿日期:2000-08-25 出版日期:2001-01-25 发布日期:2013-03-19

Experimental Study of Deep Hypothermic Cardiopulmonary Bypass Modes on Pulmonary Function

"Pediatric Thoracic & Cardiovascular Department, Xinhua Hospital affiliated to shanghai second medical school, Shanghai 200092, China,
Thoracic Cardiovascular Department, Shanghai Children’s Medical Center affiliated to shanghai second medical school, Shanghai 200127, China"

Received:2000-08-25 Online:2001-01-25 Published:2013-03-19

摘要/Abstract

摘要： 为研究深低温停循环（DHCA）和深低温低流量（DHLF）两种体外循环方法对肺功能的影响。采用幼猪模拟临床复制出DHCA和DHLF模型，于转流前、转流结束和停体外循环后1h等3个时点测定肺顺应性、气道阻力、动脉—肺泡氧分压比率、肺血管阻力指数和中性粒细胞滞留率等指标值。结果表明DHLF后，肺顺应性和动脉—肺泡氧分压比率的下降程度，肺血管阻力指数和中性粒细胞滞留率的增加程度均明显高于DHCA。两组气道阻力无差别。结果提示，DHLF较之DHCA对肺的损伤更为严重。

关键词: 深低温低流量, 深低温停循环, 肺功能, 幼猪

Abstract: The influence of Deep Hypothermic Circulatory Arrest (DHCA) and Deep Hypothermic low-flow cardiopulmonary bypass （DHLF) on lung was studied. After establishment of DHCA and DHLF model on piglcls according to clinical cardiovascular surgery, measurements of lung compliance、airway resistance. artcry-alvcolar O<sub>2</sub>pres-sure ratio、pulmonary vascular resistance and neutrophil sequestration ratio were dctcct-ed at 3 different time, i.e. before institution of Cardiopulmonary bypass (CPB) 、at the end of CPB and 1 hour after cessation of CPB. The results showed that more severe decrement of lung compliance and artery-alveolar O<sub>2</sub> pressure ratio and greater incre-ment of pulmonary vascular resistance and neutrophil sequestration ratio were observed in DHLF than in DHCA. No difference were observed on increments of airway resis-tance between the two groups. It was concluded that DHLF could cause more severe pulmonary injury than DHCA on piglels lung.

Key words: Deep hypothermic circulatory arrest , Deep hypothcrmic low-flow cardiopul-monary bypass , Pulmonary function, Piglet

杨艳敏，苏肇伉，陈恩，张海波，王顺民，邹文艳. 深低温体外循环方法对肺功能影响的实验研究[J]. , 2001, 21(1): 13-16.

YANG Yan-min,SU Zhao-kang,CHEN En,ZHANG Hai-bo,WANG Shun-ming,ZOU Wen-yan. Experimental Study of Deep Hypothermic Cardiopulmonary Bypass Modes on Pulmonary Function[J]. , 2001, 21(1): 13-16.

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