实验动物与比较医学 ›› 2016, Vol. 36 ›› Issue (1): 32-36.DOI: 10.3969/j.issn.1674-5817.2016.01.006

所属专题: 实验动物资源开发与利用

• 论著 • 上一篇    下一篇

新西兰兔脏器参数、血液指标、心率、心室压的性别间比较

张晓玉, 张修彦, 詹纯列   

  1. 广州军区广州总医院动物实验中心, 广州 510010
  • 收稿日期:2015-06-19 出版日期:2016-02-25 发布日期:2016-02-25
  • 作者简介:张晓玉(1989-), 女, 硕士, 研究方向: 人类疾病动物 模型的开发利用。E-mail: zhxiaoyu11@163.com
  • 基金资助:
    广东省科技计划基础条件建设项目(2012B060300022)

Comparison on Organ Parameter, Blood Parameter, Heart Rate and Ventricular Pressure between Male and Femele New Zealand White Rabbit

ZHANG Xiao-yu, ZHANG Xiu-yan, ZHAN Chun-lie   

  1. Animal Experiment Center, Guangzhou General Hospital of Guangzhou Military Command of PLA, Guangzhou 510010, China
  • Received:2015-06-19 Online:2016-02-25 Published:2016-02-25

摘要: 目的 测定并比较普通级新西兰兔脏器参数、血液指标、心率及心室压。方法 取70~80日龄普通级新西兰兔60只,雌雄各半,饲养一周后,精确称量体质量后,采集动脉血用于测定血液生理生化及血气指标; 呼吸支持情况下开胸进行心室压测定; 解剖取各脏器并称量。结果 性别间比较: 胸腺、肺的脏器系数差异显著(P<0.05或P<0.01); 血液指标中,嗜酸性细胞百分率、中性粒细胞百分率、单核细胞百分率、淋巴细胞百分率、中性粒细胞、单核细胞、红细胞平均体积、平均血红蛋白量、血清白/球蛋白、血糖、补体C3、谷氨酰转肽酶、pH值、pH温度校正、血氧饱和度差异均显著(P<0.05或P<0.01); 左心室舒张压、右心室舒张压差异有显著性意义(P<0.05)。结论 普通级新西兰兔部分脏器系数,血液生理生化、血气以及心室压指标性别间存在差异,用于相关实验研究时应注意。

关键词: 普通级新西兰兔, 脏器参数, 血液学指标, 心室压

Abstract: Objective To determine and compare the parameters of organ and blood, heart rate and ventricular pressure in New Zealand white rabbit. Methods A total of 60 New Zealand white rabbits about 70-80 days old were fed for a week. Weight of rabbit and main organ, blood physiological and biochemical index and blood gas, ventricular pressure and heart rate were determined on respiratory support condition. Result The thymus gland and lung organ coefficient differences were significant between male and female rabbits (P<0.05 or P<0.01). Percentage of eosinophils, neutrophils, mononuclear cell and lymphocyte, neutrophils, mononuclear cell, mean corpuscular volume, average amount of hemoglobin, serum albumin /globulin, blood glucose, complement C3, glutamyl- transpeptidase, value of pH, temperature correction pH, oxygen saturation differences were significant (P<0.05 or P<0.01). The left and right ventricular diastolic blood pressure differences were also significant(P<0.05). Conclusion Some of the organ coefficient, blood physiological and biochemical index, blood gas analysis and ventricular pressure exist significant difference between male and female New Zealand white rabbit, it should be paid attention in related research.

Key words: New Zealand white rabbit, Organ parameter, Blood parameter, Ventricular pressure

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