以NOEV[dB(C)]作为实验动物环境及设施噪声标准指标与限值的探讨

doi:10.3969/j.issn.1674-5817.2014.06.016

实验动物与比较医学 ›› 2014, Vol. 34 ›› Issue (6): 507-508.DOI: 10.3969/j.issn.1674-5817.2014.06.016

所属专题：实验动物设施设备

以NOEV[dB(C)]作为实验动物环境及设施噪声标准指标与限值的探讨

魏社林, 袁文, 蔡巧冰

广东省实验动物监测所, 广东省实验动物重点实验室, 广州510663

收稿日期:2014-05-28 出版日期:2014-12-25 发布日期:2014-12-25
作者简介:魏社林(1965-), 男, 硕士, 副研究员, 主要从事实验动物及标准化研究工作, E-mail:wesleysina@aliyun.com

Discussion on the Scientific Basis of Taking NOEV[dB(C)] as the Index and Limitation Value of Noise in Laboratory Animal Facility

WEI She-lin, YUAN Wen, CAI Qiao-bing

Guangdong laboratory Animals Monitoring Institute, Guangzhou510633

Received:2014-05-28 Online:2014-12-25 Published:2014-12-25

摘要/Abstract

摘要： 我国实验动物环境及设施国家标准GB14925-2010以及国外相关标准噪声指标采用A声级噪声值dB(A),该指标以人类的听觉特性为基础。我国噪声标准限值为≤60 dB(A),亦来源于人类听觉要求。科学事实和已有科学研究显示目前采用的指标与限值均不尽合理,本文对此进行了综述论证。同时本文综合现有研究文献,提出以最大无可见影响客观噪声值NOEV[dB（C）],No observed Effect Volume [dB(C)],作实验动物环境及设施噪声标准的指标与限值,并推断得出不同种类实验动物的NOEV[dB（C）]是不同的。具体数值需要通过新的研究方可获得,本文或可为实验动物环境及设施噪声标准的指标与限值达到科学有据提出了研究方向。

关键词: 实验动物设施, 噪声标准, 无可见影响噪声值(NOEV), C声级噪声值[dB(C)]

Abstract: The index of noise is dB(A) in the national standard for laboratory animal facility and environment of P. R. China GB14925-2010 and in relative standards of many foreign countries. This index is based on the character of human being hearing. The limitation value of the noise in standard of P. R. China is ≤60 dB(A). That is also from the demand of human being hearing. But many natural evidences and scientific researches show that the index and limitation value is not reasonable nor scientific. The writers discussed such argument based on available scientific documents. And the writers proposed that NOEV[dB(C)], No observed Effect Volume [dB(C)], could be the suitable index and limitation value for noise in laboratory animal facility and environment based on available scientific documents, and derived that NOEV[dB(C)] is different between different laboratory animals. The detailed data could be obtained by new scientific researches. The revivew pointed out the direction for how to get the limitation value of noise in laboratory animal facility and environment.

Key words: Laboratory Animal Facility, Limitation Value of Noise, No Observed Effect Volume(NOEV), dB(C)

中图分类号:

Q95-33

魏社林, 袁文, 蔡巧冰. 以NOEV[dB(C)]作为实验动物环境及设施噪声标准指标与限值的探讨[J]. 实验动物与比较医学, 2014, 34(6): 507-508.

WEI She-lin, YUAN Wen, CAI Qiao-bing. Discussion on the Scientific Basis of Taking NOEV[dB(C)] as the Index and Limitation Value of Noise in Laboratory Animal Facility[J]. Laboratory Animal and Comparative Medicine, 2014, 34(6): 507-508.

参考文献

[1] GB 14925-2010. 实验动物环境及设施[S].
[2] Allin JT, Banks EM.Effects of temperature on ultrasound production by infant albino rats[J]. Dev Psychobiol, 1971, 4(2):149-156.
[3] Carden SE, Hofer MA.Effect of a social companion on the ultrasonic vocalizations and contact responses of 3-day-old rat pups[J]. Behav Neurosci, 1992, 106(2):421-426.
[4] 陈克安. 声学测量[M].北京: 科学出版社, 2005.
[5] 沈嚎, 陈定楚, 莫中廉, 等. 强噪声场中豚鼠死亡原因的探讨[J]. 科学通报, 17:1041-1044.
[6] 山内忠平. 实验动物的环境与管理[M]. 沈德余译. 上海: 上海科学普及出版社,1989.
[7] Rabat A, Bouyer JJ, George O, et al.Chronic exposure of rats to noise: Relationship between long term memory deficits and slow wave sleep disturbances[J]. Behav Brain Res, 2006, 171: 303-312.
[8] Kim H, Lee M H, Chang H K, et al.Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats[J]. Brain Dev, 2006, 28:109-114.
[9] Manikandan S, Padma M K, Srikumar R, et al.Effects of chronic noise stress on spatial memo ry of rats in relation to neuronal dendritic alteration and free radicalism balance in hippo campus and medial prefrontal cortex[J]. Neurosci Lett, 2006, 399(1-2):17-22.
[10] 吴馥梅, 李新人, 赵长清, 等. 强噪声对小白鼠脑发育及条件反射建立的影响[J]. 环境科学, 1982, 3(6):43-45.
[11] 崔博. 噪声对神经行为功能影响的研究进展[J]. 解放军预防医学杂志, 2004, 22(5):399-401.
[12] Baldwin AL1, Schwartz GE, Hopp DH.Are investigators aware of environmental noise in animal facilities and that this noise may affect experimental data[J]. J Am Assoc Lab Anim Sci, 2007, 46(1):45-51.
[13] Turner JG1, Bauer CA, Rybak LP. Noise in animal facilities: why it matters[J]. J Am Assoc Lab Anim Sci, 2007, 46(1):10-13.

以NOEV[dB(C)]作为实验动物环境及设施噪声标准指标与限值的探讨

Discussion on the Scientific Basis of Taking NOEV[dB(C)] as the Index and Limitation Value of Noise in Laboratory Animal Facility

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