The Latest Research Progress of the Function of Spinal CD11c+ Microglia in Neuropathic Pain

doi:10.12300/j.issn.1674-5817.2022.073

Abstract

Abstract:

Neuropathic pain (NP) affects approximately 10% of the population, and treatments and drugs for NP have limited efficacy. Microglia in the spinal cord play important and paradoxical roles in peripheral nerve injury-induced NP, both promoting the development of NP and relieving NP. In April 2022, Keita Kohno et al. reported that after peripheral nerve injury, CD11c⁺ microglia appearing in the spinal cord of mice were a type of microglia that relieve NP and inhibited pain recurrence. In this commentary, we review the important findings of this type of analgesic microglia subset, and provide a perspective for future work related to this new finding.

Key words: Neuropathic pain, Microglia, CD11c, IGF1, Analgesic, Anti-inflammatory, Mice

CLC Number:

R-332

Changgeng PENG, Yan FU, Fengting ZHU, Ruilong XIA, Wei XIA. The Latest Research Progress of the Function of Spinal CD11c⁺ Microglia in Neuropathic Pain[J]. Laboratory Animal and Comparative Medicine, 2022, 42(3): 171-176.

Figures/Tables 5

References 11

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基因本体论条目 GO Term	条目P值 Term P value	相关基因Associated genes
基因本体论条目 GO Term	条目P值 Term P value	数目Number	所占比例Proportion/%	基因名称 Name
Growth factor binding	0.000 146 6	4.82	8	C3, Cd36, Cxcl 13, Flt1, Igf 2r, Il 1rn, I2rg, Pdgfa
Cytokine binding	0.002 029 6	4.20	6	Cd36, Cd44, Cxcr 4, Il 12b, Il 1rn, Il 2rg
Cytokine receptor activity	0.002 245 4	5.00	5	Cd44, Cxcr 4, F3, Il 12b, Il 2rg
Lipoprotein particle binding	0.000 389 2	10.53	4	Apoe, Cd36, Colec12, Lpl
Cytokine receptor binding	0.000 000 7	4.36	15	Ccl 22, Ccl 5, Ccl 6, Cd44, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Socs2
Cytokine activity	<0.000 000 1	6.25	15	Areg,Ccl 22, Ccl 5, Ccl 6, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Spp1
Chemokine receptor binding	0.000 012 8	8.24	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
Chemokine activity	0.000 000 4	13.73	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
CXCR chemokine receptor binding	0.000 383 9	18.75	3	Cxcl 10, Cxcl 13, Cxcl 2
CCR chemokine receptor binding	0.002 199 9	6.67	4	Ccl 22, Ccl 5, Ccl 6, Cxcl 13

基因本体论条目 GO Term	条目P值 Term P value	相关基因Associated genes
基因本体论条目 GO Term	条目P值 Term P value	数目Number	所占比例Proportion/%	基因名称 Name
Growth factor binding	0.000 146 6	4.82	8	C3, Cd36, Cxcl 13, Flt1, Igf 2r, Il 1rn, I2rg, Pdgfa
Cytokine binding	0.002 029 6	4.20	6	Cd36, Cd44, Cxcr 4, Il 12b, Il 1rn, Il 2rg
Cytokine receptor activity	0.002 245 4	5.00	5	Cd44, Cxcr 4, F3, Il 12b, Il 2rg
Lipoprotein particle binding	0.000 389 2	10.53	4	Apoe, Cd36, Colec12, Lpl
Cytokine receptor binding	0.000 000 7	4.36	15	Ccl 22, Ccl 5, Ccl 6, Cd44, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Socs2
Cytokine activity	<0.000 000 1	6.25	15	Areg,Ccl 22, Ccl 5, Ccl 6, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Spp1
Chemokine receptor binding	0.000 012 8	8.24	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
Chemokine activity	0.000 000 4	13.73	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
CXCR chemokine receptor binding	0.000 383 9	18.75	3	Cxcl 10, Cxcl 13, Cxcl 2
CCR chemokine receptor binding	0.002 199 9	6.67	4	Ccl 22, Ccl 5, Ccl 6, Cxcl 13

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