Exploration and Practice of Building a One-Stop Service Platform for Gene-Edited Mice in University Animal Centers: A Case Study of Shanghai Jiao Tong University

doi:10.12300/j.issn.1674-5817.2025.036

Abstract

Abstract:

Gene-edited mouse models, as a core tool in modern biomedical research, play an irreplaceable role in fields such as disease mechanism analysis, drug development, and gene function studies. However, universities often face challenges including technical complexity, dispersed resources, and low management efficiency during the preparation, breeding, and data analysis of gene-edited mice. To address these issues, establishing a one-stop service platform for gene-edited mice that integrates full-chain technical services and an intelligent management system has become an inevitable choice for university laboratory animal centers to break through current difficulties. This platform must possess core functions including gene-edited mouse construction, breeding and colony expansion, biological purification, strain preservation, and endangered strain rescue, forming a whole-process technical service system covering "target design - model construction - population expansion - genetic quality control - biological sample preservation", to promote the strategic transformation of university laboratory animal centers from providing "single technical services" to providing "whole-process solutions". Taking the Laboratory Animal Center of Shanghai Jiao Tong University as an example, through technical optimization, the technical defects such as low microoperation success rate and insufficient standardization of genotype identification were solved. Through traceability management and information sharing, problems such as chaotic management of mouse strains in research groups and waste of research funds caused by repeated constructions were solved. Through systematic integration and optimization of technical services, problems such as low efficiency, resource waste, and collaboration difficulties that may be caused by fragmented service systems were solved. This paper systematically discusses the construction path and practical experience of the gene-edited mouse service platform from three perspectives: intensive management, service capacity building, and support system construction, aiming to provide referable management models and implementation paths for the construction of similar platforms in other universities.

Key words: Gene-edited mice, One-stop service platform, University laboratory animal center, Intensive management, Whole-process technical service system

CLC Number:

Q95-33

NIE Yongqiang,WANG Zhaoxia. Exploration and Practice of Building a One-Stop Service Platform for Gene-Edited Mice in University Animal Centers: A Case Study of Shanghai Jiao Tong University[J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 642-648. DOI: 10.12300/j.issn.1674-5817.2025.036.

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