The Latest Research Progress of the Function of Spinal CD11c+ Microglia in Neuropathic Pain

doi:10.12300/j.issn.1674-5817.2022.073

Abstract

Abstract:

Neuropathic pain (NP) affects approximately 10% of the population, and treatments and drugs for NP have limited efficacy. Microglia in the spinal cord play important and paradoxical roles in peripheral nerve injury-induced NP, both promoting the development of NP and relieving NP. In April 2022, Keita Kohno et al. reported that after peripheral nerve injury, CD11c⁺ microglia appearing in the spinal cord of mice were a type of microglia that relieve NP and inhibited pain recurrence. In this commentary, we review the important findings of this type of analgesic microglia subset, and provide a perspective for future work related to this new finding.

Key words: Neuropathic pain, Microglia, CD11c, IGF1, Analgesic, Anti-inflammatory, Mice

CLC Number:

R-332

Changgeng PENG,Yan FU,Fengting ZHU,et al. The Latest Research Progress of the Function of Spinal CD11c⁺ Microglia in Neuropathic Pain[J]. Laboratory Animal and Comparative Medicine, 2022, 42(3): 171-176. DOI: 10.12300/j.issn.1674-5817.2022.073.

Figures/Tables 5

References 11

1	INOUE K, TSUDA M. Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential[J]. Nat Rev Neurosci, 2018, 19(3):138-152. DOI:10.1038/nrn.2018.2 .
2	CHEN G, ZHANG Y Q, QADRI Y J, et al. Microglia in pain: Detrimental and protective roles in pathogenesis and resolution of pain[J]. Neuron, 2018, 100(6):1292-1311. DOI:10.1016/j.neuron.2018.11.009 .
3	YOUNGER J, MACKEY S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study[J]. Pain Med, 2009, 10(4):663-672. DOI:10.1111/j.1526-4637.2009.00613.x .
4	SUMITANI M, UEDA H, HOZUMI J, et al. Minocycline does not decrease intensity of neuropathic pain intensity, but does improve its affective dimension[J]. J Pain Palliat Care Pharmacother, 2016, 30(1):31-35. DOI:10.3109/15360288. 2014. 1003674 .
5	CURTIN C M, KENNEY D, SUAREZ P, et al. A double-blind placebo randomized controlled trial of minocycline to reduce pain after carpal tunnel and trigger finger release[J]. J Hand Surg, 2017, 42(3):166-174. DOI:10.1016/j.jhsa.2016.12.011 .
6	KOHNO K, SHIRASAKA R, YOSHIHARA K, et al. A spinal microglia population involved in remitting and relapsing neuropathic pain[J]. Science, 2022, 376(6588):86-90. DOI:10.1126/science.abf6805 .
7	WLODARCZYK A, HOLTMAN I R, KRUEGER M, et al. A novel microglial subset plays a key role in myelinogenesis in developing brain[J]. EMBO J, 2017, 36(22):3292-3308. DOI:10.15252/embj.201696056 .
8	MCKELVEY R, BERTA T, OLD E, et al. Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation[J]. J Neurosci, 2015, 35(2):457-466. DOI:10.1523/JNEUROSCI.2315-14.2015 .
9	BROCKER T, RIEDINGER M, KARJALAINEN K. Targeted expression of major histocompatibility complex (MHC) class Ⅱ molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo [J]. J Exp Med, 1997, 185(3):541-550. DOI:10.1084/jem.185.3.541 .
10	TU Y S, MULEY M M, BEGGS S, et al. Microglia-independent peripheral neuropathic pain in male and female mice[J/OL]. Pain. (2022-04-04)[2022-05-10]. . DOI:10.1097/j.pain.0000000000002643 .
11	SUN L T, XIA R L, JIANG J W, et al. MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord[J]. Prog Neurobiol, 2021, 202:102024. DOI:10.1016/j.pneurobio.2021.102024 .

基因本体论条目 GO Term	条目P值 Term P value	相关基因Associated genes
基因本体论条目 GO Term	条目P值 Term P value	数目Number	所占比例Proportion/%	基因名称 Name
Growth factor binding	0.000 146 6	4.82	8	C3, Cd36, Cxcl 13, Flt1, Igf 2r, Il 1rn, I2rg, Pdgfa
Cytokine binding	0.002 029 6	4.20	6	Cd36, Cd44, Cxcr 4, Il 12b, Il 1rn, Il 2rg
Cytokine receptor activity	0.002 245 4	5.00	5	Cd44, Cxcr 4, F3, Il 12b, Il 2rg
Lipoprotein particle binding	0.000 389 2	10.53	4	Apoe, Cd36, Colec12, Lpl
Cytokine receptor binding	0.000 000 7	4.36	15	Ccl 22, Ccl 5, Ccl 6, Cd44, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Socs2
Cytokine activity	<0.000 000 1	6.25	15	Areg,Ccl 22, Ccl 5, Ccl 6, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Spp1
Chemokine receptor binding	0.000 012 8	8.24	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
Chemokine activity	0.000 000 4	13.73	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
CXCR chemokine receptor binding	0.000 383 9	18.75	3	Cxcl 10, Cxcl 13, Cxcl 2
CCR chemokine receptor binding	0.002 199 9	6.67	4	Ccl 22, Ccl 5, Ccl 6, Cxcl 13

基因本体论条目 GO Term	条目P值 Term P value	相关基因Associated genes
基因本体论条目 GO Term	条目P值 Term P value	数目Number	所占比例Proportion/%	基因名称 Name
Growth factor binding	0.000 146 6	4.82	8	C3, Cd36, Cxcl 13, Flt1, Igf 2r, Il 1rn, I2rg, Pdgfa
Cytokine binding	0.002 029 6	4.20	6	Cd36, Cd44, Cxcr 4, Il 12b, Il 1rn, Il 2rg
Cytokine receptor activity	0.002 245 4	5.00	5	Cd44, Cxcr 4, F3, Il 12b, Il 2rg
Lipoprotein particle binding	0.000 389 2	10.53	4	Apoe, Cd36, Colec12, Lpl
Cytokine receptor binding	0.000 000 7	4.36	15	Ccl 22, Ccl 5, Ccl 6, Cd44, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Socs2
Cytokine activity	<0.000 000 1	6.25	15	Areg,Ccl 22, Ccl 5, Ccl 6, Csf 1, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2, Il 12b, Il 1b, Il 1rn, Mif, Osm, Spp1
Chemokine receptor binding	0.000 012 8	8.24	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
Chemokine activity	0.000 000 4	13.73	7	Ccl 22, Ccl 5, Ccl 6, Cxcl 10, Cxcl 13, Cxcl 14, Cxcl 2
CXCR chemokine receptor binding	0.000 383 9	18.75	3	Cxcl 10, Cxcl 13, Cxcl 2
CCR chemokine receptor binding	0.002 199 9	6.67	4	Ccl 22, Ccl 5, Ccl 6, Cxcl 13

[1]	WANG Juan, XU Jiahui, TIAN Yunyuan, ZHANG Mengmeng, LI Min, WANG Siwang, LI Yao. Comparison and Behavioral Observation of Two Female Mice Models of Ulcerative Colitis [J]. Laboratory Animal and Comparative Medicine, 2026, 46(3): 332-343.
[2]	LI Longxue, WAN Chongfan, ZHANG Qi, LEI Ruting, WANG Xiaoyue, CHENG Leyan, LAI Qi, LIU Ronghua, LIU Xuan, XU Tielong. Molecular Mechanisms of Qingfei Paidu Decoction in the Prevention and Treatment of Acute Lung Injury in Mice Based on miRNA Sequencing [J]. Laboratory Animal and Comparative Medicine, 2026, 46(3): 311-320.
[3]	AI Xiufeng, ZHANG Lizong, FANG Mingsun, LÜ Dongying, CHEN Chu, CAI Zhaowei, WANG Dejun. Analysis of Differences in the Intestinal Flora of Rats and Mice after Drinking Chlorinated Water Based on 16S rRNA Sequencing [J]. Laboratory Animal and Comparative Medicine, 2026, 46(3): 437-445.
[4]	RONG Wenshuang, NIU Yuanfei, LIU Meiting, YANG Mengyuan, CUI Shuang, MA Lina, FU Yao, WANG Lianmei, CAO Junling. Influence of Antigen Type on the Establishment of an Induced Sjögren Syndrome Mouse Model [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 178-190.
[5]	WU Xianwen, LIU Lili, CHEN Ye, XU Guoheng. Optimization of Cage-Changing Intervals and Wood Shavings Usage for Mice During the Growth Phase in Breeding Systems [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 251-260.
[6]	LIU Sai, FU Bin, LI Sidi, CHEN Zhida, ZHANG Yue, GUO Zhongkun, WANG Yongan, WANG Kezhou. Adra2a Regulates LPS-Induced Inflammation in Hepatocytes of Lbp^-/- Mice via the MAPK Signaling Pathway [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 212-221.
[7]	ZHAO He, ZHANG Tao, LI Li, XIAO Yuzhou, AN Xuefang, ZHANG Fan. Enhancement Effect of Porcine Inhibin Polyclonal Antibody on Superovulation in C57BL/6J Mice [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 271-278.
[8]	CUI Changwan, LU Yiping, YU Miao, WANG Shuang, WU Si, SUN Zhengrong. Inhibitory Effect of Solute Carrier Family 7 Member 5 Inhibitor JPH203 on Renal Fibrosis Induced by Unilateral Ureteral Obstruction in Mice [J]. Laboratory Animal and Comparative Medicine, 2026, 46(2): 205-211.
[9]	XU Bo, CHEN Tairen, FANG Qian, WU Ji. Research on Spatiotemporal Gene Expression Profiles and Repair Mechanisms of Spinal Cord Compression and Hemisection Spinal Cord Injury Mouse Models [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 32-45.
[10]	XU Yingtao, WANG Mengmeng, LIN Ping, CHI Haitao, WANG Yi, BAI Ying. Exosomes Treat Ischemic Stroke by Regulation of Ferroptosis Through the NRF2/SLC7A11/GPX4 Pathway in Mice [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 20-31.
[11]	YANG Lin, JIN Meng, WU Hanqing, LI Shun, ZHOU Xiaohui. Establishment and Preliminary Analysis of an AG6 Mouse Encephalopathy Model Induced by Vaccinia Virus Tiantan Strain Infection [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 3-10.
[12]	LIU Chang, XIANG Xuesong, HE Huihuang, CHEN Xiaoqing, QIU Wenhong. Establishment and Evaluation of an Oxidative Stress Model of Atopic Dermatitis Induced by 2,4-dinitrofluorobenzene [J]. Laboratory Animal and Comparative Medicine, 2026, 46(1): 46-54.
[13]	LIU Song, MO Qianru, WANG Jin, CUI Ying, TIAN Ling. Main Biological Characteristics of Hermetia illucens L. and Its Potential Applications as a Model Organism [J]. Laboratory Animal and Comparative Medicine, 2025, 45(6): 803-809.
[14]	NIE Yongqiang, WANG Zhaoxia. Exploration and Practice of Building a One-Stop Service Platform for Gene-Edited Mice in University Animal Centers: A Case Study of Shanghai Jiao Tong University [J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 642-648.
[15]	WANG Chao, LI Shun, REN Xiaonan, YANG Hua, CHEN Lixiang, XU Chunhua, ZHOU Xiaohui. Aging Inhibits Memory Immune Response of CD8⁺ T Cells in Lungs of C57BL/6J Mice Against Influenza A (H1N1) Virus [J]. Laboratory Animal and Comparative Medicine, 2025, 45(5): 515-523.